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Wnt信号通路与纤维化疾病关系的研究进展 被引量：9

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摘要 纤维化是指器官组织内纤维结缔组织增多，实质细胞减少。纤维化可发生于肺、心肌、肝脏、肾脏等多处器官和组织，持续进展可致器官结构破坏和功能减退，甚至出现器官功能衰竭。Wnt信号通路参与调控细胞的分化、癌变、凋亡及机体免疫、应激等生理病理过程。近期研究证实：Wnt信号通路的异常与各种纤维化疾病，如肝、肺、肾脏等组织器官纤维化的发生与进展关系密切。本文就Wnt信号通路参与纤维化疾病的研究进展综述如下。
作者 龚文颖 曾林祥
机构地区 南昌大学第二附属医院
出处 《天津医药》 CAS 北大核心 2013年第9期935-936,共2页 Tianjin Medical Journal
关键词 纤维化 肺纤维化 肝硬化 肾疾病 心肌 WNT蛋白质类 信号传导
分类号 R73-37 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Wu J, Cohen SM. Repression of Teashirt marks the initiation of wing development [J]. Development,2002,129( 10):2411-2418.
  • 2Lie DC, Colamarino SA, Song HJ, et al. Wnt signalling regulates adult hippocampal neumgenesis[J].Nature,2005,437(7063):1370- 1375.
  • 3陶忠桦,李洪.Wnt信号转导通路与组织器官纤维化[J].西南军医,2010,12(3):531-533. 被引量：3
  • 4Park S, Lee EJ. Recent advances in idiopathic pulmonary fibrosis[J]. Tuberc Respir Dis (Seoul),2013,74(1):1-6.
  • 5Kim TH, Kim SH, Seo JY, et al. Blockade of the Wnt/b-catenin pathway attenyates bleomycin-induced pulmonary fibrosis [J]. To- hoku J Exp Med,2011,223(1):45-54.
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二级参考文献19

  • 1Jiang F, Parsons CJ, Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellatc ceils implicates Wnt signaling pathway in activation [ J ]. J Hepatol, 2006,45 (3) :401 - 409.
  • 2Colston JT, de la Rosa SD, Koehler M, et al. Wnt - induced secreted protein -1 is a prohypertrophic and profibrotic growth factor [ J]. Am J Physiol Heart Circ Physiol, 2007,293 (3) : H1839 - 1846.
  • 3Bayle J, Fitch J, Jacobsen K, et al. Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis [ J ]. J Invest Dermatol, 2008,128(4) :871 -881.
  • 4Sato M. Upregulation of the Wnt/beta - catcnin pathway induced by transforming growth factor - beta in hypertrophic scars and keloids [J]. Acta Derm Venereol, 2006,86(4):300-307.
  • 5Kolligs FT, Bommer G ? keB. Wnt/beta - eatenin/tef signaling ; acritical pathway in gastrointestinal tumorigenesis [ J ]. Digestion, 2002,66 (3) :131 - 144.
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  • 7Habas R, He X. Activation of Rho and Rac by Wnt/ffizzled signaling [J]. Method s Enzymol, 2006,406:500 -511.
  • 8Veeman MT ,Axelrod JD ,Moon RT. A second canon :functions and mechanisms of beta - catenin - independent Wnt signaling [ J ]. Dev Cell,2003,5 (3) :367 - 377.
  • 9Tsukamoto H ,She H, Hazra S,et al. Anti - adipogenic regulation underlies hepatic stellate cell transdifferentiation [ J ]. J Gastroenterol Hepato1,2006 ,21 (3) :S102 - 105.
  • 10Myung SJ, Yoon JH, Gwak GY, et al. Wnt signaling enhances the activation and survival of human hepatic stellate cells [ J]. FEBS Lett, 2007,581 (16) :2954 -2958.

共引文献12

同被引文献77

引证文献9

二级引证文献58

天津医药
2013年 第9期

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