摘要
目的 探讨脑缺血再灌注后神经细胞内蛋白激酶 C(PKC)的激活与游离钙的变化与神经细胞调亡的关系。方法 线栓法制做大鼠脑缺血再灌注模型；磷基转移法测定 PKC活性变化。结果 PKC在脑缺血再灌注后出现了易位激活，细胞内游离钙含量增多及神经细胞调亡 。结论 脑缺血再灌注后 PKC和钙相互作用共同促进了神经细胞的凋亡。
Objective To probe into the relation of PKC activated the change of intracellular free calcium content with neuronal apoptosis .Method Focal cerebral ischemia/reperfusion model was esteblished in wistar with suture method ;PKC activity was measured with phosphoryl abevacuation .Result PKC was activated after cerebral ischemia /reperfusion ,increased intreased intracellular free calcium content induced neuronal apoptosis.Conclusion The interrelantion of calcium and PKC induced neuronal apoptosis after cerebral ischemin/reperfusion .
出处
《现代康复》
CSCD
2000年第11期1668-1669,共2页
Modern Rehabilitation
