摘要
目的 观察国产羟乙膦酸钠治疗骨质疏松症的疗效。方法 羟乙膦酸钠组 68例 ,服羟乙膦酸钠二疗程共 6个月 ,对照组 4 8例 ;2组每日均服碳酸钙 0 .6g,维生素 D12 5单位 ,连续半年。结果羟乙膦酸钠组腰椎及髋部 BMD均升高 ,骨痛明显改善 ,与此同时 ,血清碱性磷酸酶、骨钙素、酸性磷酸酶及尿吡啶酚 /肌酐比值明显降低 ,对照组用药前后无明显改变。不良反应轻。结论 羟乙膦酸钠是治疗原发性骨质疏松症安全、有效、方便。
Objective\ To observe the efficacy of China made etidronate disodium(ET)in treating primary osteoporosis.Method\ 68 cases of osteoporosis were treated with ET for two courses (400mg per morning for 14 days and three months for one course).The control group consisted of 48 cases.The two groups were all treated with calcium carbonate\|vitamin D 0 6g q.n.for half a year.Result \ The bone mineral density of lumbar vertebra and hip was increased and bone pain was alleviated in ED group.Serum ALP,ACP,BGP and urine Pyd/Cr ratio were significantly decreased while the control group had no obvious change.The side effect of ED was slight. Conclusion\ ED is an effective medicine for treating primary osteoporosis and is characterized by safety,convenience and economy.
出处
《中国骨质疏松杂志》
CAS
CSCD
2000年第4期58-60,32,共4页
Chinese Journal of Osteoporosis
关键词
原发性
骨质疏松症
羟乙膦酸钠
治疗
骨密度
Osteoporosis Etidronate disodium Bone mineral density Treatment
