摘要
本文以骨计量学方法和有关血、骨生化测定探讨不同剂量羟乙膦酸钠周期口服对雌性大鼠去势后骨质疏松症的防治作用。结果表明：（１）适当剂量羟乙膦酸钠使去势大鼠骨小梁骨量和骨钙量较未给药组不同程度地增加，从而可以有效地减缓因雌激素减少而致的骨丢失速度，（２）周期性口服羟乙膦酸钠（连续５天后停药２５天再重复循环）在有效减少骨吸收，降低骨转换率，减少骨丢失的同时可避免对骨形成和骨重建的不利影响，（３）低剂量（２５ｍｇ／ｋｇ体重／日）周期口服效果最佳，不仅在骨小梁骨量和骨钙方面，且骨转换率参数如骨小梁形成表面百分比、活性生成表面百分比、骨矿化沉积速率和骨形成速率显著优于高剂量（５１ｍｇ／ｋｇ体重／日），亦优于中剂量（３６ｍｇ／ｋｇ体重／日）。
Thetherapeuticeffectsofintermitentcyclicetidronatedisodium(HEBP)ofdifferentdosesonovariectomy-inducedosteoporosiswerestudied.53femaleWistarrats,weighingwithanaver-ageof266gmwererandomlydividedinto5groups.Gourp1hadbilateralovariectomy(OVX)andwasgivenlowdoseHEBPof25mg/kgBW/day;group2hadOVXandgivenmediumdoseHEBPof36mg/kgBW/day;group3hadOVXandgivenhighdoseHEBPof51mg/kgBW/day;group4hadOVXandgroup5hadshamOVX.HEBPwasadministratedoralyduringfastingfor5daysfolowedbyarestperiodof25daysandtheregimewasrepeatedfor3times.Alanimalsweresacrificedat90thdayafterOVX.RadioimmunoassayofserumestradiolconfirmedthesuccessofOVX.TheserumCaandPcon-tent,AKPaseactivity,femoralrelativedryweight,CaandPcontentwereanalysedrespectively.Therighttibiaewereprocessedundecalcifiedforquantitativebonehistomorphometry.TheresultsshowedthatthebonecalciumcontentandtrabecularbonevolumeofOVX-ratstreatedwithHEBP,especialywiththelowdosegroupwerehigherthanthatofthesimplyOVX-ratandtheboneturnoverparameterssuchasAKPaseactivity,boneformationsurface,boneresorptionsurface,activeformationsurface,bonemineralappositionrateandboneformationratewerelowerthanthoseofthesimplyOVX-rat.TheresultsindicatetheHEBPcouldretardthedegreeofosteopososisthroughreducingtheelevatedboneresorptionandboneturnoverinducedbyOVX.Meanwhile,theresultssuggestthattheefectoflowdoseHEBP(25mg/kgBW/day)wasmoreefectivethanthatofthehighdose.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1996年第9期581-584,共4页
Chinese Journal of Orthopaedics
关键词
骨质疏松
羟乙膦酸钠
更年期
女性
OsteoporosisEtidronate-disodiumHistomorphometryOvariectomizedrats
