摘要
目的 探讨应用雌激素、降钙素、维生素 D3和钙剂对去势家兔骨质疏松模型股骨上端骨折愈合的作用。方法 16只雌性青紫兰家兔去势复制骨质疏松模型 ,行股骨上端骨折克氏针内固定。术后随机分为两组 ,实验组给予益钙宁、尼尔雌醇、维生素 D3及钙剂观察对骨折愈合的影响。结果 X射线片示实验组较对照组外骨痂生成量多 ,骨折愈合时间缩短。股骨的极限扭矩和最大刚度增加。QCT检测腰 2～ 4椎体松质骨骨密度皆增加。结论 骨质疏松并骨折除内固定外 ,还要联合应用抑制骨吸收 ,并促进骨形成的药物 。
Objective\ To investigate the effect of combined treatment of internal fixation,hormone replacement therapy(HRT),calcitonin,vitamin D 3 and calcium supplementaion on osteoporosis associated with upper femoral fracture in rabbits.Methods\ 16 seven month old female rabbits were bilaterally ovariectomized to set up the osteoporosis model.The upper femoral fracture and intramedullary nail fixation were made operatively.After that,the subjects were divided into two groups randomly;one received HRT,calcitonin,vitamin D 3 and calcium supplementation,and the other placebo for 8 weeks.Results The experimental group showed decreased bone resorption,accelerated bone formation,a shorter period of fracture healing and a higher torque and stiffness of bone,compared with the control group.X ray showed more callus,and SPA,QCT showed higher BMD of L 2～4 than in the control group. Conclusion Patients with osteoporosis associated with upper femoral fracture may benefit from drugs used to treat osteoporosis besides operation.
出处
《中国骨质疏松杂志》
CAS
CSCD
2000年第4期20-22,9,共4页
Chinese Journal of Osteoporosis
关键词
骨质疏松模型
联合用药
骨折愈合
Osteoporosis Femur fracture Combined treatment Rabbits
