摘要
目的:探讨首次发病的青少年精神分裂症患者执行功能及其与精神症状的关系。方法:采用威斯康星卡片分类测验(WCST)及韦克斯勒记忆量表第3版(WMS-Ⅲ)空间广度测验测试75例首次发病的青少年精神分裂症患者(病例组)和80名健康对照者(对照组)的执行功能;病例组同时应用阳性和阴性症状量表(PANSS)评定病情。结果:病例组WCST的错误总数、持续反应数和持续错误数显著高于对照组,正确总数显著低于对照组(P均<0.01);WMS-Ⅲ总分和空间广度逆行分显著低于对照组(P均<0.05)。病例组PANSS阴性症状分与WMS-Ⅲ空间广度逆行分及总分负相关(r=-0.276,r=-0.230;P均<0.05);阳性症状分与WCST完成分类数负相关(r=-0.258,P<0.05);一般病理学总分与WMS-Ⅲ空间广度逆行分负相关(r=-0.244,P<0.05)。结论:首次发病的青少年精神分裂症患者执行功能显著受损,并与病情有关。
Objective：To investigate the executive function in adolescent patients with first-episode schizophrenia.Method：The executive function tests including wisconsin card sorting Test （WCST） and Wechsler memory scale-Ⅲ （WMS-Ⅲ） spatial span test were performed in 75 adolescent patients with first-episode schizophrenia （cases group） and 80 normal controls （control group）.Meanwhile,the condition of the patients were assessed by positive and negative symptoms scale （PANSS）.Results：In WCST,the total number of errors,continuous reaction number and number of continue to wrong in cases group were significantly higher than control group,the total number of correct was significantly lower than control group （all P0.01）.In WMS-Ⅲ,the total score and spatial span backward score in cases group were significantly lower than control group （all P0.05）.In cases group,the negative symptoms score was negatively correlated with WMS-Ⅲ spatial span backward and total scores （r=-0.276,r=-0.230;all P0.05）;the positive symptom score was negatively correlated with WCST categories completed scores （r=-0.258,P0.05）;the general psychopathology score was negative correlation with WMS-Ⅲ spatial span backward score（r=-0.244,P0.05）.Conclusion：The executive function in adolescent patients with first-episode schizophrenia shows impairment and which is correlated with illness.
出处
《临床精神医学杂志》
2013年第4期255-257,共3页
Journal of Clinical Psychiatry
基金
"十一五"国家科技支撑计划课题基金资助项目(2007BAII7B04)
关键词
精神分裂症
首次发病
执行功能
schizophrenia
first-episode
executive function
