摘要
目的观察中西医联合治疗系统性红斑狼疮的临床疗效,并初步探讨T淋巴细胞亚群与该病发病机制的关系。方法将我院收治的33例SLE患者随机分为对照组和治疗组,对照组采用常规激素与CTX治疗,治疗组在对照组基础上加用中药益气养血健脾补肾方。观察患者治疗前后免疫指标及血常规变化,并针对T淋巴细胞亚群的变化水平分析与SLE之间的关系。结果经过治疗后,治疗组总有效率为94.4%,对照组为80.0%,治疗组显著高于对照组(P<0.05);治疗组抗ds-DNA、ANA、抗-RNP、CIC转阴率显著优于高于对照组(P<0.05)。两组患者治疗后免疫球蛋白及相关补体均较治疗前显著下降(P<0.05);其中治疗组免疫球蛋白IgM、IgA、IgG下降水平明显优于对照组,两组间具有统计学差异(P<0.05),而相关补体C3、C4下降水平无统计学差异(P>0.05);两组患者治疗后CD4与CD4/CD8均明显升高(P<0.05)。结论 T淋巴细胞亚群可能SLE的发病有关,益气养血健脾补肾方联合西药治疗SLE疗效确切,值得临床推广。
Objective To observe the clinical effect of integrated Chinese - western medicine in treating SLE , and investigate the rela- tionship of T lymphocyte subsets and the pathogenesis of the disease. Methods 33 cases of SLE patients were randomly divided into control group and treatment group , the control group treated by routine hormone and CTX, the treatment group treated the same as control group and Chinese medicine. Observe the changes of immune indexes and blood of patients before and after treatment, and analyze the relationship be- tween SLE and level change of subsets of T lymph bacteria. Results After treatment, the total effective rate of treatment group was 94.4%, 80% in the control group, the treatment group was significantly higher than that of the control group（P 〈 0.05）, The treatment group of ds - DNA, ANA, - RNP, CIC negative conversion rate was significantly higher than that of control group（ P 〈 0.05 ）, Two groups of patients af- ter treatment with immunoglobulin and complement significantly lower than before treatment （P 〈 0.05 ） ; treatment group of immunoglobulin IgM, IgA, IgG decrease was significantly better than the control group, with significant difference between the two groups （P 〈 0.05）, and complement C3, C4 no significant precipitation flat the difference （ P 〉 0.05 ） ; the two group patients after CD4 and CIM/CD8 were signifi- cantly increased （ P 〈 0.05 ）. Conclusion T lymph bacterial subpopulations may effect SLE pathogenesis, integrated Chinese - western ther- apy SLE is better than only western medicine , and worth the clinical promotion.
出处
《湖北中医药大学学报》
2013年第4期25-27,共3页
Journal of Hubei University of Chinese Medicine
关键词
系统性红斑狼疮
中西医结合疗法
益气养血健脾补肾方
SLE
Integrated Chinese -western therapy
supply Qi and blood and strengthen spleen and kidney decoction
