摘要
目的运用彩超评价高血压内皮微颗粒(EMPs)水平对肱动脉内皮功能的影响。方法采用流式细胞术检测高血压患者30例和健康志愿者30例血浆中EMPs的水平,比较两组对肱动脉内皮功能的影响。结果 2组在年龄、性别、体重指数、总胆固醇、甘油三酯、空腹血糖、吸烟等指标上差异均无统计学意义(P>0.05)。与健康志愿者组相比,高血压患者循环EMPs水平显著升高(P<0.01);高血压组患者肱动脉内皮舒张功能(FMD)减低(P<0.01),循环EMPs水平与FMD值呈负相关(r=-0.142,P<0.01)。结论提示高血压病患者体内较高水平的循环EMPs是肱动脉内皮舒张功能减低的影响因素,彩色多普勒可作为诊断及观察疗效的一项重要手段。
[ Objective] To evaluate the influence of endothelial microparticle （EMPs） level on brachial artery endothelial function in hypertension patients by color Doppler flow imaging （CDFI）. [ Methods] The plasma EMPs levels in 30 hypertension patients and 30 healthy volunteers were examined by flow cytometry, and the influence on braehial artery endothelial function was compared between two groups. [ Results] The differences in age, sex, body mass index, total cholesterol, triglyceride, fasting blood glucose and smoking were not significant between two groups （ P 〉 0. 05 ）. Compared with healthy volunteers, the level of circulating EMPs in hypertension patients significantly increased （ P 〈 0. 01 ） , and the flow-mediated dilation （ FMD ） significantly decreased （P 〈0.01）. There was a negative correlation between the level of circulating EMPs and the value of FMD （r =-0. 142, P 〈 0.01 ）. [ Conclusion] h is suggested that higher level of circulating EMPs in hypertension patients may reduce the braehial artery endothelial dilation function, and CDFI could play an important role in diagnosis and clinical observation.
出处
《职业与健康》
CAS
2013年第17期2254-2256,共3页
Occupation and Health
基金
广州市医药卫生科技项目(201102A213185)
关键词
彩超
高血压
内皮微颗粒
肱动脉
Color Doppler uhrasound
Hypertension
Endothelial microparticles
Brachial artely
