摘要
目的 探讨急性肺损伤的治疗方法。方法 建立大鼠急性肺损伤模型 ,随机分成 3组 ,筛选药物己酮可可碱治疗 ,检测支气管肺泡灌洗液中性白细胞及巨噬细胞比例和肺通透指数 ,肺组织湿重 /干重 ,肺血管通透性 ,一氧化氮 (NO)、诱生性一氧化氮合成酶 (iNOS)、内皮素 (ET)测定和肺组织大体、病理观察。结果 治疗组与内毒素组比较 ,中性白细胞比例下降 ,肺通透指数减低 ,肺血管通透性下降 ,NO、iNOS、ET明显下降 ,肺组织大体明显改善 ,病理观察损伤肺组织修复 ;与生理盐水组差异不明显。
Objective To explore a therapeutic method for acute lung injury.Methods Wistar rat models of Lipopolysacharide(LPS)-induced acute lung injury(ALI) were randomly divided into the model group(group A),the pentoxifylline group (group B)and the saline solution group (group C).The ratio of the neutrophile and the macrophage in the bronchoalveolar lavage fluid (BALF) and lung permeability index (LPI) were observed.The lung wet weight/dry weight and the pulmonary microvascular permeability index (PMPI)were also analyzed respectively.The serum Nitric oxide (NO),Endothelium(ET)levels and the lung inducible NO,ET levels and the lung inducible nitric oxide synthnase (iNOS)activity were analyzed.The surface and histological appearance of lung were observed under microscope and electromicroscope.Results There were more obvious changes in ratio of the neutrophile and the macrophage,LPT,lung wet weight/dry weight,PMPI,NO,ET,iNOS activity and the surface and histological appearance of lung in group B than that in group A,and there were no significantly difference in group B and in group C.Conclusion It suggests pentoxifylline can obvious improve the Lipopolysacharide-induced ALI. [
出处
《中国急救医学》
CAS
CSCD
北大核心
2000年第10期573-575,共3页
Chinese Journal of Critical Care Medicine
