摘要
目的 探讨缓激肽 ( BK)对大鼠尾动脉活动产生的影响 ,以及 BK受体在大鼠尾动脉的种类分布。方法 用 Biopac系统进行张力测定 ,观察实验结果。结果 BK有收缩大鼠尾动脉的作用 ,且呈量效关系。这种缩血管作用不受内皮细胞存在与否的影响 ,不受 B1受体阻断剂和激动剂的影响 ,但可被 B2受体阻断剂阻断。结论 在大鼠尾动脉平滑肌细胞仅存在 B2 受体亚型 ,且该试验可作为研究 B2 受体的模型。
Objective To observe the influence of bradykinin on rat tail arteries.Method Measurement of isometric contraction force of rat tail artery strips by Biopac system.Result BK was found to contract rat tail artery tissues in a concentration-dependent manner.This effect of BK independent of the presence of endothelium.The application of B 1 receptor antagonist or agonist did not affect the basal force or BK-induced vasocontraction.BK-induced vasocontraction was,however,abolished by various B 2 receptor antagonists.Conclusion The studies established a reliable model to study the vasocontraction evoked by B 2 receptor activation. [
出处
《潍坊医学院学报》
2000年第4期249-251,共3页
Acta Academiae Medicinae Weifang
关键词
缓激肽
平滑肌细胞
血管收缩
Bradykinin
Smooth muscle cell
Vasocontraction
