摘要
目的:探讨我院药品不良反应(ADR)发生的规律及特点。方法:对我院2008年收集到的117例ADR报告,分别从患者性别、年龄、药品剂型、给药途径、合并用药情况、药品种类分布,累及器官或系统及临床表现分布等方面进行回顾性分析。结果:117例ADR中,女性69例(58.97%),多于男性48例(41.03%);41～50岁为ADR多发人群(23.93%);ADR主要由静脉滴注给药引起(86.32%);ADR涉及10大类药品共46种,其中抗微生物药引发ADR例数最多(58.97%),包括9类共20种;ADR临床表现最常见的为皮肤及其附件损害(54.70%);117例ADR治愈或好转,无死亡病例。结论:临床应合理使用药品,重视特殊人群用药安全。
OBJECTIVE：To probe into the general regularity and characteristics of ADR in our hospital. METHODS：117 ADR reports were analyzed retrospectively in respect of the patient’s gender,age,dosage form,route of medication,medication combination,category of drugs,involved organs and system and clinical manifestation,ect. RESULTS：Of total 117 cases of ADR,female cases of 69 accounted for 58.97% while 48 male cases 41.03%. ADR cases were mainly found in the group aged from 41 to 50（23.93%）. ADR was predominantly caused by intravenous drip infusion（86.32%）. 46 kinds of drugs in 10 categories were involved,in which antimicrobial drug took dominate place including 20 kinds in 10 categories（58.97%）. The most common clinical symptom represented as lesion of skin and its appendants（54.70%）. 117 cases were cured and improved without death case. CONCLUSION：Great importance should be attached to rational use of drug and safety of drug use of special population.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第14期1323-1325,共3页
China Pharmacy
