摘要
目的比较氯丙嗪和利培酮对首发精神分裂症患者认知功能的影响。方法将100例首发精神分裂症住院患者随机分为氯丙嗪组(50例)和利培酮组(50例),进行开放性对照研究。在治疗前和治疗后第8周末各做1次韦氏成人智力量表(WAIS-R)、韦氏记忆量表(WMS)和威斯康星卡片分类测验(WCST)。结果治疗第8周末,利培酮组各项认知功能检查结果明显好于氯丙嗪组(P<0.05);在控制可能的干扰因素(入组时测查水平、年龄、文化程度、药物副反应的程度)后,大部分检查结果两组之间差异仍显著,利培酮组各项认知功能指标均有好转,而氯丙嗪组6项中有3项恶化。结论对首发精神分裂症患者,利培酮治疗对其认知功能有改善作用,而氯丙嗪对认知功能的某些方面有损害。
Objective To explore the effect of chlorpromazine and risperidone on cognitive function of the patients with first episode, schizophrenia. Methods 100 first episode schizophrenic patients were treated randomly with chlorpromazine or risperidone. WAIS-R, WMS, WCST were evaluated before treatment and after 8 weeks treatment. Results The congnitive function of patients treated with risperidone was better than with chlorpromazine after 8 weeks treatment（P〈0.01～0. 05）. After controlling for pretreatment test results, age, educational level, and extrapyramidal syndrome side effect. Most factors of cognitive test in risperidone group got better, but 3 of 6 factors got worse in chlorpromazine, Conclusion Risperdone can improve cognitive function otherwise chlorpromazine can impair cognctive function in first-rpisode schizophrenic patients.
出处
《中国健康心理学杂志》
2005年第5期342-344,共3页
China Journal of Health Psychology
