摘要
目的:探讨他汀类药物降低高脂血症的临床疗效,分析其用药的安全性。方法:采用普伐他汀(pravastatin)和辛伐他汀(simvastatin)对本院就诊的68例高脂血症患者分别给药治疗,并对两组临床疗效进行客观评价。结果:本研究中的两种他汀类药物降低血脂均有显著效果,其中普伐他汀组患者的总有效率为84.85%;辛伐他汀降脂效果比普伐他汀更优异(总有效率达94.29%),两组比较差异有统计学意义(P<0.05)。结论:辛伐他汀和普伐他汀均能促进细胞内胆固醇的代谢,有效降低高血脂,且辛伐他汀比普伐他汀疗效更显著,为临床应用他汀类药物用药安全提供科学依据,具有重要的临床实践意义。
Objective： To investigate the effect of simvastatin on genes related to high blood lipids, security analysis of the drug use.Method： To treatment 68 cases of hyperlipidemia patients in our hospital with using pravastatin （ pravastatin ） and simvastatin （ simvastatin ）, to evaluation of the clinical efficacy of the two groups.Result： Blood lipids had a significant effected wifh two kinds of statins in this study, the total efficiency of the pravastatin groups was 84.85%; Lipid-lowering effect of simvastatin was more excellent than pravastatin （ the total effective rate was 94.29% ）, two groups were significant difference （ P〈0.05 ） .Conclusion： Simvastatin and pravastatin can promote cholesterol metabolism in cells, effectively reduce the high blood lipids, and simvastatin effect was more significant than pravastatin, provide scientific basis for the clinical application of statin drug safety, has important implications for clinical practice.
出处
《中国医学创新》
CAS
2013年第23期43-44,共2页
Medical Innovation of China
