摘要
目的探讨阿托伐他汀与辛伐他汀治疗原发性高脂血症的临床药理疗效。方法选择广东省湛江市第二人民医院2009年8月～2011年12月原发性高脂血症患者112例,分为观察组(n=56)与对照组(n=56),观察组采用阿托伐他汀治疗,对照组采用辛伐他汀治疗,治疗2个月后比较两组患者的血脂变化及不良反应。结果两组患者治疗后TC、TG、LDL-C、HDL-C水平与治疗前相比,差异有统计学意义(P<0.05),观察组治疗后TC、TG、LDL-C、HDL-C水平明显优于对照组,差异有统计学意义(P<0.05)。观察组疗效明显优于对照组,两组总有效率比较差异有统计学意义(P<0.05),两组不良反应率比较,差异无统计学意义(P>0.05)。结论阿托伐他汀与辛伐他汀均具有较好的降脂作用,但阿托伐他汀在原发性高脂血症治疗中疗效较好,值得临床推广。
Objective To explore the clinical pharmacological effects of atorvastafin and simvastatin in the treatment of efsential hyperlipidemia. Methods 112 case of primary hyperlipidemia admitted to our hospital from Aug. 2009 to Dec. 2010 were randomly divided into observation group and control group, with 56 cases in each group. The observation group was treated with atorvastatin and the control group was given simvastatin. The serum lipids and adverse reactions were observed and compared between the two groups. Results After treatment, the level of TC, TG, LDL-C, HDL-C were significantly better than those before treatment in the two groups （P〈0.05）. After treatment, the level of TC, TG, LDL-C, HDL-C in the observation group were superior to those in the control group （P〈0.05）.The total effective rate of the observation group was significantly higher than that of the control group （P〈0.05）.Thete was no significant difference of the adverse reactions between the two groups （P〉0.05）. Conclusion Both atorvastatin and simvastatin is effective to lower lipi,ds. But atorvastatin is much better in treating essential hyperlipidemia, which is worthy of clinical application.
出处
《当代医学》
2012年第21期131-132,共2页
Contemporary Medicine
关键词
阿托伐他汀
辛伐他汀
原发性高脂血症
疗效
Atorvastatin
Simvastatin
Essential hyperlipidemia
Curative effect
