摘要
目的 评价膀胱部分切除术治疗肌层浸润膀胱癌的效果。方法 对近 10年间采用膀胱部分切除术治疗的 4 8例肌层浸润 (T2 ,T3)的膀胱移行上皮癌进行随访分析 ,平均随访时间 97 5个月。膀胱部分切除术后辅以膀胱内BCG免疫治疗或化疗者 4 6例 ,使用BCG者 15例 ,使用噻替哌者 2 1例 ,使用丝裂霉素者8例 ,BCG和丝裂霉素交替使用者 2例。结果 术后 60个月 ( 5年 )内复发者 2 3例 ( 4 7 9% )。肿瘤复发与肿瘤体积、数量、分期分级和膀胱内灌注的不同药物均有关系 ,体积较大、多发的、分期分级高的肿瘤复发率高 ,术后辅以膀胱内BCG免疫治疗者复发率低 ,丝裂霉素化疗者次之 ,噻替哌化疗者复发率较高。死亡 19例( 39 6% ) ,T2 期 5年存活率为 60 4 % ,T3期 5年存活率 38 9%。总体 5年存活率为 60 4 %。结论 膀胱部分切除术在T2
Objective To evaluate effectiveness of partial cystectomy for muscle infiltrating bladder cancer. Methods 48 cases of muscle infiltrating transitional cell carcinoma(stages T 2 and T 3)treated by partial cystectomy in past 10 years were followed up and analyzed.Mean follow up period of time was 97.5 months.Postoperative intravesical instillation of BCG was undergone in 15 cases,mitomycin in 8 cases and thiotepa in 21 cases. Results Tumor recurred in 23 cases(47.9%)within 60 months (5 years)period postoperatively.Tumor recurrence was associated with tumor size,number,stage,grade and different intravesical medicine.Higher rate of recurrence was found in those with bigger tumor size,more than one tumors,higher stage and grade.Lower rate of recurrence was found in those with postoperative intravesical instillation of BCG and mitomycin,but those with thiotepa had a little higher recurrence.19 cases died within 60 months postoperatively,5 year survival rate was 73.3% in T 2,38.9% in T 3,respectively.Total 5-year survival rate was 60.4%. Conclusion Partial cystectomy still played a certian role in the treatment of T 2 muscle infiltrating bladder cancer.
出处
《兰州医学院学报》
2000年第1期19-20,共2页
Journal of Lanzhou Medical College
