摘要
采用卵母细胞体外培养的方法研究了硝酸铅、氯化镍对小鼠卵母细胞成熟的影响。结果表明 ,硝酸铅、氯化镍都能抑制小鼠卵母细胞第一极体的释放 ,降低卵母细胞的质量和体外存活率 ,但是对卵母细胞生发泡破裂没有影响。提示 ,硝酸铅、氯化镍有明显的生殖毒性。
The effect of lead nitrate and nickel chloride on maturation and meiosis of mouse oocyte in vitro was studied.The results showed that lead nitrate and nickel chloride could inhibit the release of the first polar body and affect the quality and viability of mouse oocyte,but had little impact on the germinal vesicle breakdown.It indicates that lead nitrate and nickel chloride have obvious reproductive toxicity.
出处
《苏州医学院学报》
2000年第8期694-695,共2页
Acta Academiae Medicinae Suzhou
关键词
硝酸铅
氯化镍
卵母细胞
生殖毒性
小鼠
Lead nitrate
Nickel chloride
Oocyte
Germinal vesicle breakdown
First polar body
