摘要
研究细胞周期蛋白 (cyclinD1 )、细胞增殖核抗原 (PCNA)在胸腺瘤中表达及意义。方法 :用免疫组织化学方法 (S P)法 ,检测 1 8例良性胸腺瘤、2 0例侵袭性胸腺瘤和 1 6例胸腺癌标本cyclinD1、PCNA。结果 :在 3组胸腺肿瘤中cyclinD1阳性表达分别为 5 1 8( 2 7 78% )、1 3 2 0 ( 6 5 0 0 % )、1 4 1 6 ( 87 5 0 % ) (P <0 0 5 ) ;PCNAⅢ—Ⅳ指数分别为 :5 1 8( 2 7 78% )、1 5 2 0 ( 75 0 0 % )、1 3 1 6 ( 81 2 5 % ) (P <0 0 5 )。cyclinD1、PCNA阳性表达与胸腺瘤的类型、临床分期、淋巴结转移、生存率等参数有关。结论 :cyclinD1、PCNA参与胸腺瘤细胞的增殖并影响其分化 。
Purpose:To study the expression of cyclin D1 and PCNA in thymomas and its significance. Methods:Immunohistochemical method was used to examine the sections from 18 thymomas, 20 invasive thymomas and 16 thymic carcinomas. Results:The positive ratios of cyclin D1 were 5/18 (27.78 %),13/20(65 00 %),14/16(87 50 %)(P<0 05);The positive ratios of PCNA were 5/18(27.78%),15/20(75 00%),13/16(81 25%)(P<0 05) in the three thymoma groups, respectievly. The positive ratios of cyclin D1 and PCNA protein were related to the histopathology, clinical stage and prognosis. Conclusions:cyclin D1 and PCNA protein are involved in the proliferation and influence differentiation of thymoma, which can be used as an useful index for prognosis monitoring.
出处
《中国癌症杂志》
CAS
CSCD
2000年第4期339-341,共3页
China Oncology
