摘要
目的 :探讨cyclinD1、p16、Rb蛋白在胸腺瘤中表达及预后意义。 方法 :应用免疫组化S P法 ,对 5 4例胸腺瘤标本进行检测。结果 :cyclinD1、p16、Rb蛋白在髓质型、混合型胸腺瘤中阳性表达率分别为 2 3 1% (3/13 )、6 9 2 % (9/13)、5 3 9% (7/13) ,器官样、普通皮质型胸腺瘤中阳性表达率分别为 5 0 0 % (8/16 )、75 0 % (12 /16 )、75 0 % (12 /16 ) ,高分化、高级别胸腺癌中阳性表达率分别为 84 0 % (2 1/2 5 )、40 0 % (10 /2 5 )、5 6 0 % (14/2 5 ) ,(P <0 0 5 )。cyclinD1、p16蛋白的阳性表达与胸腺瘤的M H分型、临床分期、淋巴结转移、预后密切相关。结论 :cyclinD1、p16、Rb蛋白参与胸腺瘤细胞增殖并影响其分化 。
Purpose To explore the expression and significance of cyclinD1, p16 and Rb protein in thymoma. Methods Immunohistochemical method was used for examinating the sections from 54 thymomas. Results The positive rates of cyclinD1, p16 Rb were 23 1%(3/13),69 2%(9/13),53 9%(7/13) in the medullary and mixed thymoma. The positive rates of were 50 0%(8/16), 75 0%(12/16),75 0%(12/16) in the cortical. The positive rates of were 84 0%(21/25), 40 0%(10/25),56 0%(14/25), in the well differentiated thymic carcinoma and well grede thymic carcinoma; respectively, ( P <0 05 ). The positive rates of cyclinD1, p16 and Rb protein had relation with the histologic subtyping, clinical stage and prognosis in the thymoma. Conclusion cyclinD1, p16 and Rb protein are involved in cell proliferating and influence differentiation of thymoma,which can be adapted as an useful index for prognosis monitoring.
出处
《临床与实验病理学杂志》
CAS
CSCD
2000年第4期304-306,共3页
Chinese Journal of Clinical and Experimental Pathology
