摘要
目的:探讨体外受精-胚胎移植(IVF-ET)中各因素与单卵双胎(monozygotic twins,MZT)妊娠的相关性。方法:对本中心3 966个妊娠周期(含MZT 35例)和另30例(含MZT 1例)胚胎植入前遗传学诊断(PGD)妊娠周期的临床资料行非条件Logistic回归分析,筛选单卵双胎发生的相关因素。回顾分析11 423个新鲜胚胎移植周期的临床资料,将其分为激光辅助孵化(AH)组和未行辅助孵化(非AH)组,比较2组中IVF周期和胞浆内单精子注射(ICSI)周期的单卵双胎发生率。结果:Logistic回归分析结果表明ICSI-AH(OR=1.039,95%CI:1.013～1.065)可能是IVF中单卵双胎妊娠发生的危险因素。非AH组行IVF 4 624个周期,ICSI1 571个周期;AH组行IVF 3 807个周期,ICSI 1 421个周期,2组组内患者基本情况差异无统计学意义(P>0.05)。非AH组IVF与ICSI周期临床妊娠率(40.72%vs.42.76%)和单卵双胎率(0.69%vs.0.75%)差异均无统计学意义(P>0.05);AH组IVF与ICSI周期临床妊娠率(27.97%vs.29.77%)差异无统计学意义(P>0.05),但ICSI周期的单卵双胎率高于IVF周期(2.31%vs.0.66%,P<0.05)。结论:行激光辅助孵化的ICSI周期可能增加单卵双胎发生率。
Objective： To investigate the correlation between those risk-factors of in vitro fertilizationembryo transfer（IVF-ET）and monozygotic twins（MZT） gestation.Methods：3 966 clinical pregnancy cycles,including 36 MZT cycles,were analyzed by Logistic regression.According to fertilization methods and with or without laser-assisted hatching（LAH）,total of 11 423 IVF/intracytoplasmic sperm injection（ICSI）cycles were divided into nonAH-IVF group（4 624 cases）,nonAH-ICSI group（1 571 cases）,LAH-IVF group（3 807 cases）and LAH-ICSI group（1 421 cases）.The incidences of MZT were compared.Results：LAH-ISCI（OR= 1.039,95% CI：1.013 ～1.065） may be a risk factor of MZT pregnancy in IVF-ET.There were no significant differences in general condition between nonAH groups and LAH groups,and no significant differences in clinical pregnancy rate（40.72% vs.42.76%）and MZT rate（0.69% vs.0.75%）between nonAH-IVF group and nonAH-ICSI group（P〉0.05）.MZT rate was significantly higher in LAH-ICSI group than that in LAH-IVF group（2.31% vs.0.66%,P〈0.05）,while there was no significant difference in the pregnancy rate between the two groups（27.97% vs.29.77%,P〉0.05）.Conclusions：LAH-ICSI might increase the occurrence of MZT.
出处
《国际生殖健康／计划生育杂志》
CAS
2013年第4期275-277,308,共4页
Journal of International Reproductive Health/Family Planning
关键词
受精
体外
胚胎移植
激光
胚胎培养技术
双生
单卵
透明带
显微操作
妊娠率
Fertilization in vitro
Embryo transfer
Lasers
Embryo culture techniques
Twins
monozygotic
Zona pellucida
Micromanipulation
Pregnancy rate
