摘要
目的:探讨检测N-末端脑钠肽前体(NT-proBNP)与同型半胱氨酸(Hcy)在老年心力衰竭诊断和治疗中的临床应用价值。方法:选取我院心血管内科收治的208例老年心力衰竭患者为心衰组,选取同期在我院体检中心体检的90例健康受试者为健康对照组,检测两组血清NT-proBNP和Hcy水平及其左心室射血分数,并进行对比分析。结果:心衰组的血清NT-proBNP与Hcy水平显著高于健康对照组;且随着心功能分级的上升,血清NT-proBNP与Hcy水平均显著上升;心力衰竭控制后的血清NT-proBNP与Hcy水平均较控制前有显著下降;而左心室射血分数则较控制前有显著提高,差异均有统计学意义(P<0.05)。血清NT-proBNP与Hcy水平均和左心室射血分数呈负相关,而血清NT-proBNP水平与血清Hcy水平之间呈正相关(P<0.05)。结论:血清NT-proBNP与Hcy水平的检测对老年心力衰竭的早期诊断、近期临床疗效判断以及患者预后的评估均有一定的参考意义,值得在临床上进一步推广应用。
Objective：To investigate the clinical value of N-terminal pro-brain natriuretic peptide（NT-proBNP）and Homocysteine（Hcy）detection in the diagnosis and treatment of senile heart failure.Methods：A total of 208senile patients with heart failure in our hospital were selected as heart failure group,and 90cases of health subjects as control group.The levels of NT-proBNP and Hcy and the left ventricular ejection fraction of the two groups were tested and comparaed.Results：The levels of NT-proBNP and Hcy in the heart failure group were significantly higher than the control group,and with the increase in NYHA,the levels of NT-proBNP and Hcy were significantly increased in heart failure group（all P0.05）.The levels of NT-proBNP and Hcy were significantly decreased when heart failure was controlled,and the left ventricular ejection fraction was significantly increased（P0.05）.The levels of NTproBNP and Hcy were negatively correlated with left ventricular ejection fraction（r=-0.71,-0.77）,and the level of NT-proBNP was positively correlated with the level of Hcy level（r=0.65）,（all P 0.05）.Conclusions：The detection of the levels of NT-proBNP and Hcy is helpful in early diagnosis,judgment of curative effect and prognosis of senile heart failure,and it is worthy further clinical application.
出处
《海南医学院学报》
CAS
2013年第9期1234-1237,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210780)~~
