1Humphrey LL,Fu R, Rogers K, et al. Homocysteine level and coronary heart disease incidence: a systematic review and meta analysis. Mayo Clin Proc, 2008,83 : 1203-1212.
5Gu W, Lu J, Yang G, et al. Plasma homocysteine thiolactone associated with risk of macrovasculopathy in Chinese patients with type 2 diabetes mellitus. Adv Ther, 2008,25:914-924.
6Nasir K,Tsai M,Rosen BD,et al.Elevated homocysteine is associated with reduced regional left ventricular function:the Multi-Ethnic Study of Atherosclerosis.Circulation,2007,115:180-187.
7Schofield RS,Weasel TR,Walker TC.et al.Hyperhomocysteinemi-a in patients with heart failure referred for cardiac transplantation:preliminary observations.Clin Cardiol,2003,26:407-410.
8Vasan RS,Beiser AD,Agostino RB,et al.Plasma homocyste and risk for congestive heart failure in adultswithout priormyoc dial infarction.JAMA,2003,289:1251-1257.
1Rubany I. The role of endothelium in cardiovascular homeostasis and disease. C ardiovasc Pharmacol, 1993,22 : S 1-13.
2Behrendt D, Ganz P. Endothelial function:from vascular biology to clinical applications. Am J Cardiol, 2002,90 : 401-481.
3Doshi SN, McDowell IFW, Moat SJ, et al. Folic acid improves en--dothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation,2002,105:22-26.
4Gupta A, Moustapha A, Jacobsen DW, et al. High homocys- teine,low folate and low vitamin B6 concentra-tions Prebalant risk factors for vascular disease in heart tuansplant recipients. Transplantation, 1998,65 : 540-550.
5Robinson K, Arheart K, Refsum H, et al. Low circu-lating fo- late and vitamin B6 concentrations, risk factors for stroke, periph- eral vascular disease ans coronary artery disease European CO- MAC Group. Circulation, 1998,97 : 437-443.
6Celemajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 1992,340 : 1111-1115.
7Clark R, Daly L, Robinson K, et al. Hyperhomocystemia :an in- dependent risk factor for warscular disease. N Eng J Med, 1991, 324: 1149-1155.
8Tawakol A, Omland T, Gerhard M, et al. Hyperhomocys teinemia is associated with impaired endothelium depend ent vasodilation in humans. Circulation, 1997,95 : 1119-1121.
9Homocystenine-lowefing Trialists Collaboration. Lowering blood homocysteine with folic acid based supplements. Br Med J, 1998,316 : 894-898.
10Doshi SN, Mcdowe11 FW, Moat SJ, et al. Folic acid improve endothelial function in coronary disease via mechanisms largely independent of homocysteine lowering. Cirulation, 2002,105 : 22-26.
