摘要
目的 观察血管紧张素转换酶抑制剂Ｅｎａｌａｐｒｉｌ和Ｆｏｓｉｎｏｐｒｉｌ对ＳＨＲ心脏血管重塑逆转作用。方法 将１０月龄１８只ＳＨＲ（ＳＨＲ１０）随机分为Ｅｎａｌａｐｒｉｌ（ＳＨＲＥ）、Ｆｏｓｉｎｏｐｒｉｌ（ＳＨＲＦ）和生理盐水（ＳＨＲＣ）三组，给药剂量为１０ｍｇ／ｋｇ／ｄ腹腔内注射连续８周。测定血压、心室重量指数，用偏振光镜观察心脏、血管结构改变。图象分析计算心肌间质胶原面积、含量。结果 两药物均使心室肥厚不同程度消退，部分逆转心肌、间质、血管的结构改变，心肌间质胶原容积分数（ＣＶＦ）降低，而且Ｆｏｓｉｎｏｐｒｉｌ降低ＬＶＷ／ＢＷ比Ｅｎａｌａｐｒｉｌ更好（Ｐ＜０．０５）。结论 福辛普利、依那普利可逆转ＳＨＲ心肌、间质、血管重构，改善心肌僵硬度。
Objective This study observed the effects of angiotension converting enzyme inhibitor Enalapril & Fosinopril on reversion of ventricular remodeling in spontaneously hypertensive rats. Methods 18 SHRs were divided into three groups at random. enalapril, fosinopril or saline (10mg/kg/d) was injected intraperitoneally into rats of each group rat respectively. Systolic blood pressure and ventricular weight index (LVW/BW, RVW/BW) were measured. Picrosirus Red staining was used to determine cardiovascular morphology of collagen with polarization microscope and image analyzer system (IAS) to estimate interstitial collagen volume fraction (CVF). Results The effect of enalapril and fosinopril was similar in decreasing SBP, RVW/BW and CVF. Fosinopril was better than enalapril in decreasing LVW/BW (P<0.05). Conclusion Enalapril and fosinolpril lead to reversing the ventricular remodeling and improving cardiomuscular stiffness.
出处
《重庆医科大学学报》
CAS
CSCD
2000年第3期242-244,共3页
Journal of Chongqing Medical University
关键词
自发性高血压
大鼠
心室重构
福辛早
依那普利
Spontaneously hypertensive rats
Ventricular remodeling
Fosinopril
Enalapril
Collagen
