摘要
目的 研究前列腺非典型腺瘤性增生(AAH)的诊断和鉴别诊断.方法 以10个病例13个病灶为对象,采用HE和免疫组化染色,显微镜下观察和测量.结果 AAH病灶的范围从48至285个腺泡,腺泡小,多呈圆形,排列紧密.腺泡被覆单层细胞,核均有轻度的多形性,核仁的平均直径0.66～0.72um.病灶的边缘整齐.免疫组化CK34βE12染色显示,部分腺泡的基底细胞层不完整.结论 AAH具有特定的形态学诊断标准,CK34βE12在鉴别诊断中具有重要作用,AAH的主要临床意义是与前列腺癌的鉴别诊断.
[Abstract] Objective Diagnosis and differential diagnosis of atypical adenomatous hyperplasia of the prostate (AAH) were studied.Methods Paraffin embedded tissues of 13 foci with AAH from lOcases were studied using HE and immunohistochemical method .Results Each focus composed of acinars ranged from 48 ~ 285 with smooth border .Acinars were mostly round, tightly packed, lined by single layer of cells, nuclus were uniform with nucleoli 0.66~0.72um in mean size.CK34BE 12 immunohistochemical reaction revealed a fragmented dixcontinuous basal cell layer .Conclusion Moerphologic diagnostic criterior of AAH was established, while defecting CK34B12 immunohistochemicaly plays an important role in differential diagnosis.Clinical significance of AAH lies in that it should be differentiated from prostatic carcinoma.
