摘要
目的 :检测P53、c_erb_B2、Bcl_2在原发性肺癌中的表达 ,探讨其表达的临床意义和相互之间的关系。方法 :采用LSAB法检测 99例原发性肺癌中三种癌蛋白的表达情况 ,并分析三者表达的相关性及与肺癌的临床因素的相关性。结果 :99例原发性肺癌中有 54例P53蛋白呈细胞核阳性表达 (54.5% ) ;非小细胞肺癌中P53的表达在≥ 50岁组明显高于 <50岁组 (P <0 .0 1) ,且与Be1_2的表达相关 (P <0 .0 5) ;c_erb_B2在肺腺癌中的表达显著高于鳞癌 (P <0 .0 0 5)和小细胞癌 (P <0 .0 0 5) ;肺小细胞肺癌中Bcl_2的表达高于肺鳞癌 (P <0 .0 5)和肺腺癌 (P <0 .0 1)。结论 :c_erb_B2、Bcl_2的表达与肺癌的组织学类型有关 ;P53的表达与年龄有关 ,而与性别、淋巴结的转移无关。
To investigate the clinical significance of the expressions of P 53 ,c_erb_B 2 and Bcl_2 proteins and their mutual relationship in primary lung cancer. Methods:LSAB method was used to detect the expressions of the three oncoproteins in cancer specimens of 99 cases with primary lung cancer,and the correlations among them as well as that between the expressions and the clinical factors. Results:Nuclear location of P 53 protein was found in 54 out of the 99 cases (54 5%). In non_small cell lung cancer the positive rate of P 53 expression in the group with ages older than 50 years was higher than that in the group with ages younger than 50 years (P<0 01),and the expression of P 53 was correlated with that of Bcl_2 (P<0 05). The expression of c_erb_B 2 was significantly higher in adenocarcinoma than that in squamous lung cancer (P<0 005) and small cell lung cancer (P<0.005),and that of Bcl_2 in small cell lung cancer was obviously higher than in squamous lung cancer (P<0 05) and in adenous lung cancer (P<0 01). Conclusion:There seem to be some associations between the expressions of the three oncoproteins and the histopathological types of primary lung cancer;the expression of P 53 protein is probably associated with patient′s age but not with sex or the situation of lymphonodi in lung cancer.
出处
《广州医学院学报》
2000年第1期28-31,共4页
Academic Journal of Guangzhou Medical College
