摘要
目的探讨c-erb-B2、拓扑异构酶Ⅱα(TopoⅡα)在乳腺癌组织中的表达及临床意义。方法采用免疫组化法检测110例乳腺癌石蜡切片标本中c-erb-B2和TopoⅡα的表达。结果 110例乳腺癌组织中,c-erb-B2阳性表达率为21.8%,TopoⅡα阳性表达率为56.4%。c-erb-B2表达与淋巴结转移状态、临床分期相关(P<0.01);TopoⅡα与肿瘤细胞雌激素受体(ER)状态相关(P<0.05)。TopoⅡα与c-erb-B2表达呈正相关(P<0.01)。结论 c-erb-B2、TopoⅡα在乳腺癌组织中的高表达与乳腺癌的发生发展密切相关,联合检测c-erb-B2、TopoⅡα对于乳腺癌的化疗具有指导意义,也是判断预后的重要指标。
Objective To investigate the expression and significance of c-erb-B2 and DNA topoisomeraseⅡα（TopoⅡα） in breast cancer.Methods c-erb-B2 and TopoⅡα expressions were detected in 110 cases of breast cancer tissues by immunohistochemistry.Results The expression of c-erb-B2 was positively correlated with lymph nodes metastasis and clinical stage（P0.01）.The expression of TopoⅡα was positively correlated with estrogen receptor（ER） status（P0.05）.The expression of TopoⅡα was significantly correlated with the expression of c-erb-B2（P0.01）.Conclusion Overexpressions of c-erb-B2 and TopoⅡα are related with progression of breast cancer.Combined detection of c-erb-B2 and TopoⅡα expressions may play an important role in guiding chemotherapy and predicting prognosis.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第5期541-543,共3页
Jiangsu Medical Journal
