摘要
目的 :对载药毫微粒主要质量指标载药量、包封率及其关系 ,粒径及其分布进行研究。方法 :以阿柔比星 A聚乳酸毫微粒为研究对象 ,以分光光度法测定载药量与包封率 ,以激光粒度分析仪测定粒径及其分布。结果 :阿柔比星 A聚乳酸毫微粒平均载药量为 18.5 % ,平均包封率为 86 .7% ,平均数目径为 80 nm,平均体积径为 2 30 nm。结论 :载药量与包封率之间具有一定关系 。
A polylactide nanoparticle of aclarubicin A was prepared and the main characteristics such as, the drug loading (DL), the embedding ratio (ER), and relationships between the diameter and the distribution of nanoparticle were investigated. The DL and ER were determined by UV, while the diameter and the distribution were determined by laser mastersizer TM . Results showed that the mean DL and ER were 18.5% and 86.7%; and the mean number diameter and the mean volume diameter were 80 and 230nm respectively. It was concluded that relationships between DL and ER; as well as the volume diameter distribution are important characteristics for the preparation of aclarubicin A polylactide nanoparticle.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第4期272-273,301,共3页
Chinese Journal of Antibiotics
基金
国家自然科学基金!资助项目 (合同号 :39570 842 )
国家医药技术创新博士项目!(合同号 :95- B- 0 9)
关键词
阿柔比星A
毫微粒
载药量
包封率
聚乳酸
Aclarubicin A
Nanoparticle
Drug loading
Embedding ratio
Diameter
