摘要
目的载三氧化二砷乳酸羟基乙酸共聚物(polylactic-co-glycolic ac id,PLGA)纳米粒的制备及其工艺优化。方法以PLGA为载体材料,采用w/o/w型乳化溶剂挥发法制备载As2O3纳米粒,通过均匀设计试验优化处方和制备工艺。结果在优化条件下制备的纳米粒形态圆整、大小均匀,平均粒径为178.2 nm,平均包封率为53.19%,平均载药量为0.64%。结论本纳米粒制备工艺简单,质量可控。
Objective To study the preparation of polylactic-co-glycolic acid （PLGA） nanoparticles carrying arsenic trioxide （As2O3 ）. Methods Polymer PLGA was used to prepare arsenic trioxide nanoparticles with w/o/w double-emulsion evaporation technique, which was optimized by uniform design test. Results The shape of As2O3-1oaded PLGA nanoparticle was round, the size was well-distributed, the mean diameter was 178.2 nm, the average encapsulation ratio reached 53.19% , and the average drug loading was 0.64%. Conclusion The technique to prepare nanoparticles is simple and the quality can be easily controlled.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2006年第11期1249-1251,共3页
Journal of Third Military Medical University
