摘要
目的观察临床早期应用替罗非班对ST段抬高型心肌梗死患者急诊介入术后再灌注及心功能的影响。方法 70例ST段抬高型心肌梗死患者随机分为研究组(35例)和对照组(35例),研究组在急诊介入术基础上加用替罗非班,而对照组只采取急诊介入术,然后观察两组患者心肌缺血再灌注损伤,住院期间主要心血管事件。结果研究组术后90分钟心电图相关导联ST段回落幅度明显大于对照组,肌酸激酶峰值浓度明显低于对照组,(1 657.52±326.14)U/L vs(2 519.83±459.76)U/L(P<0.01),血管终末段显影祯数少于对照组,(18.12±4.34)祯vs(23.33±5.45)祯(P<0.01),ST段下移程度比显示末端血管灌注优于对照组(68.14±12.57)%vs(53.20±11.14)%(P<0.05)。结论急诊PCI联合应用替罗非班治疗ST段抬高型心肌梗死患者可改善心肌的灌注,明显降低心肌缺血再灌注损伤的发生率。
Objective To evaluate the effects of tirofiban on reperfusion in patients with ST-segment elevation myocardial infarction（STEMI） after primary percutaneous coronary intervention（PCI）.Methods Seventy patients with STEMI who underwent primary PCI were randomly divided into two groups,tirofiban＋ PCI group（n=35） and PCI without tirofiban group（control group,n=35）.Myocardial reperfusion,myocardial ischemia-reperfusion injury,the major adverse cardiac events（MACE） in the hospital and side effects were observed.Results 90 minutes after the operation,ECG ST-segment elevation in tirofiban＋ PCI group was much greater than that of control group,peak creatine kinase concentration significantly lower than that of control group,（1 657.52±326.14） U/L vs（2 519.83±459.76） U/L（P0.01）,the number of developed frame of terminal vessel was lower than that of control group,（18.12±4.34） frame numbers vs（23.33±5.45） frame numbers（P0.05）,the end of the vascular perfusion was superior over control group（68.14±12.57） % vs（53.20±11.14）%（P0.05）.Conclusion Tirofiban combined with primary PCI can improve myocardial perfusion in patients with STEMI,and reduce the incidence of myocardial ischemia-reperfusion injury.
出处
《临床荟萃》
CAS
2013年第8期866-867,871,共3页
Clinical Focus
关键词
心肌梗死
血管成形术
经腔
经皮冠状动脉
替罗非班
再灌注
myocardial infarction
angioplasty
transluminal
percutaneous coronary
tirofiban
reperfusion
