摘要
吡非尼酮是一种新型抗纤维化药物,近年来通过大量临床试验,证明吡非尼酮主要通过下调一系列细胞因子的表达抑制细胞增殖,在肝、肺、肾等全身各组织器官和组织中发挥抗纤维化作用,具有安全、有效及毒副作用小等特点,在临床试验中被用于各种纤维化疾病的治疗。纤维化在青光眼或白内障术后、各种增生性玻璃体视网膜病变中起着重要作用,因此研究者将吡非尼酮试用于眼科增生性病变的研究,本文就吡非尼酮的特点及其在全身和眼科的抗纤维化研究做一综述。
· Pirfenidone is a novel antifibrotic agent that has shown potential in numbers of models and clinical trials. Pirfenidone could inhibit cells proliferation through down- regulating a series of cytokines. Pirfenidone＇s antifibrotic effect and its safety have been established in organs such as liver, kidney and lung. Current application especially the department of ophthalmology and future researches on Pirfenidone were summarized in this literature.
出处
《国际眼科杂志》
CAS
2013年第8期1569-1571,共3页
International Eye Science
基金
眼科学国家重点实验室开放课题
云南省应用基础研究项目联合专项(No.2010CD162)~~
关键词
吡非尼酮
抗纤维化
增殖
Pirfenidone
antifibrotic
prolifetation
