摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者血清铁蛋白（SF）、铁调素的变化及其临床意义。方法选取经多导睡眠监测确诊为OSAS的男性患者51例，其中单纯OSAS组36例（轻度OSAS组13例，中重度OSAS组23例），OSAS合并糖尿病组15例；另选取单纯2型糖尿病（T2DM）患者14例作为T2DM组；设立单纯肥胖男性18例为对照组。分别检测各组受试者空腹血糖、HbAlc及空腹胰岛素水平，并用ELISA法检测SF、铁调素水平，观察OSAS患者sF、铁调素对糖代谢的影响。结果（1）轻度OSAS组、中重度OSAS组、OSAS合并糖尿病组和T2DM组的sF水平升高，分别为（268．24±47．94），（316．45±49．36），（377．66±49．95），（286．01±45．53）μg／L，均高于对照组（203．28±32．83）μg／L，差异有统计学意义（F=39．38，P〈0．01）；铁调素水平下降，分别为（66．41±12．00），（47．34±13．35），（34．52±8．49），（54．45±8．25）μg／L，均低于对照组（88．26±12．34）μg／L，差异有统计学意义（F=67．80，P〈0．01）。（2）SF、铁调素与睡眠呼吸紊乱指数、最长呼吸暂停时间、夜间血氧饱和度低于90％的时间占总睡眠时间的百分比、最低血氧饱和度存在相关性（r=-0．65～0．34，P均〈0．01），且SF与铁调素之间存在线性相关（F=22．40，P〈0．01）。结论0SAS患者存存SF及铁调素7k平的异常．可能存T2DM的发牛中发挥一定的作用。
Objective To explore the changes and clinical significance of serum ferritin （SF）and hepcidin in patients with obstructive sleep apnea hypopnea syndrome （OSAS）. Methods 51 cases of male patients with OSAS, diagnosed by polysomnography were selected,which included simple OSAS group 36 cases （mild OSAS group 13 eases,moderate and severe OSAS group 23 cases） ,OSAS with diabetes group 15 cases. 14 patients with simple type 2 diabetes mellitus（T2DM） were selected as T2DM group. And selected 18 obese men as control group. Measured the levels of fasting plasma glucose （FPG）, HbA1 c and fasting insulin of each group. SF and hepcidin levels were tested by enzyme-linked immunosorbent assay（ ELISA）, and their effects on glyeometabolism in paitents with OSAS were observed. Results （1）The levels of SF in mild OSAS group, moderate and severe OSAS group, OSAS with diabetes group and T2DM group were （ 268.24 ± 47. 94 ） , （316.45 ± 49.36）, （377.66 ± 49.95 ）, （286.01± 45.53 ）μg/L respectively, and were higher than that in the control group [ （203.28 ± 32.83 ） μg/L ], the differences were statistically significant （ F = 39.38, P 〈 0.01 ）. The levels of hepcidin were decreased, which were （ 66.41 ± 12.00 ）, （ 47.34 ± 13.35）, （ 34.52 ± 8.49 ）, （54.45 ± 8.25 ） μg/L respectively, and were lower than that in the control group [ （ 88.26 ± 12.34） μg/L ], the differences were statistically significant （ F = 67.80 ,P 〈 0.01 ）. （ 2 ） SF and hepcidin were correlated with apne-a-hypopnea index,the blood oxygen saturation less than 90% of the percentation of total sleep time,longest ap-nea time, minimum blood oxygen saturation （ r = - 0. 65 - 0.34, all P 〈 0.01 ） ; SF had linear correlation with hepcidin（ F = 22.40 ,P 〈 0.01 ）. Conclusion SF and hepcidin levels in OSAS patients are obvious abnormal, and may play roles in the occurrence of T2DM.
出处
《国际内分泌代谢杂志》
北大核心
2013年第4期221-225,共5页
International Journal of Endocrinology and Metabolism
