摘要
目的探讨肾移植后BK病毒活化情况对移植肾功能的影响。方法88例-肾移植受者分别于术后0．5、1、2、3、6、9和12个月采集尿液和血液，应用实时定量聚合酶链反应方法检测BK病毒DNA载量。结果88例肾移植受者中，发生BK病毒尿症27例，发生率为30．7％，其中持续性17例，一过性10例；37．0％（10／27）的BK病毒尿症继续发展为病毒血症，其中持续性和一过性者各5例，移植肾病理活检确诊BK病毒肾病（BKVAN）4例。持续BK病毒血症受者的BK病毒DNA载量较一过性者显著升高，差异有统计学意义（P〈0．05），诊断为BK病毒血症时血清肌酐显著升高，差异有统计学意义（P〈0．05）。结论肾移植术后BK病毒血症进展时移植肾功能受损，定期规律检测BK病毒及临床干预BK病毒血症能有效预防移植肾功能损伤。
Objective To investigate the influence of BK virus （BKV） activation in renal transplant recipients on the renal allograft function. Method Recipients receiving renal transplantation during 2010. 3- 2011.4 were selected as objectives, the urine and peripheral blood samples of them were taken and real-time PCR assays were performed to detect BKV DNA at 0. 5, 1,3,6,9, and 12 months post-transplantatiorL Results Among 88 recipients, BKV viruria occurred in 27 （30. 68%） patients, and sustained viruria occurred in 17 patients. 37. 0% （10/27） of patients with BKV viruria developed inot BKV virernia, and sustained virernia occurred in 5 patients. The viral load in plasma was higher in patients with sustained virernia than in those with transient virernia （P^0. 05）, and serum creatinine concentrations were higher when BK viremia occurred （P〈0. 05）. Conclusion Graft function was impaired among patients with BK viremia, and regularly monitoring BK virus in renal transplant recipients and clinical intervention based on plasma PCR results can prevent transplant kidney damage effectively.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2013年第7期404-406,共3页
Chinese Journal of Organ Transplantation
基金
北京市科技专项2011阶梯计划项目（Z111102055311086）
关键词
肾移植
BK病毒
Kidney transplantation
BK virus
