摘要
肥厚型心肌病扩张期是肥厚型心肌病的终末期改变,病理特征为心腔整体的扩大、室壁的弥漫性纤维化及小动脉管腔闭塞。肥厚型心肌病扩张期的发生与遗传因素、微循环障碍、炎症反应、氧化应激及酒精等多种因素密切相关。尽管肥厚型心肌病扩张期发病率较低,但是往往症状严重,一般药物治疗疗效不佳,通常需要心脏移植。
Summary Dilated-phase of hypertrophic cardiomyopathy （DPHCM） is the end-stage evolution of hyper- trophic cardiomyopathy, whose pathological features of DPHCM are dilated left ventricular chamber, disseminated fibrosis in ventricular wall and occluded intramural arterioles. The genetic factors, microcirculation dysfunction, inflammation and oxidative stress play critical roles in the pathological process of DPHCM. Although the occur- rence of DPHCM from classic HCM is very low, the prognosis is ominous. The conventional therapy is ineffec- tive. Cardiac transplantation is reported as the most effective treatment of DPHCM.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2013年第7期486-488,共3页
Journal of Clinical Cardiology
关键词
肥厚型心肌病
扩张期
炎症反应
微循环障碍
氧化应激
hypertrophic eardiomyopathy
dilated phase
inflammation
microcirculation dysfunction
oxida-tive stress
