摘要
目的探讨血浆N末端脑利钠肽前体(NT-proBNP)在心力衰竭的诊断以及预后中的临床应用价值。方法设心力衰竭组102例,对照组55例,测定、分析血浆NT-proBNP水平与心功能级别、左室舒张末内径(LVDD)、左室射血分数(LVEF)的关系。出院复查1次,随访患者6个月内再入院率。结果心力衰竭患者血浆NT-proBNP水平随美国纽约心脏病协会(NYHA)心功能分级级别的增高而升高(P<0.05),与LVDD呈正相关,与LVEF呈负相关。心力衰竭患者出院时NT-proBNP升高组较对照组6个月内因心力衰竭再住院率明显增高(P<0.05)。结论 NT-proBNP是诊断心力衰竭较可靠指标,与心力衰竭严重程度密切相关,动态观察NT-proBNP变化水平,对评价心力衰竭治疗效果和判断心力衰竭患者预后有重要的临床价值。
Objective To explore the clinical application value of plasma NT-proBNP in the diagnosis and prognosis of heart failure. Methods A total of 102 patients with heart failure and 55 healthy controls were selected, To determine plasma NT-proBNP and analyse its relationship with left ventricular diastolic diameter （LVDD）, left ventricular ejection fraction （ LVEF ） and cardiac function class. NT-proBNP was reexamined when the patients were discharged from hospital. The readmission rate in 6 months were followed up. Results The plasma NT-proBNP level was increased with the increase of NYHA grading in the patients with heart failure （P〈0.05）. The positive correlation between NT-proBNP and LVDD and the negative correlation between NT-proBNP and LVEF were observed. NT-proBNP was increased at discharge from hospital, the rehospitalization rate in 6 months was obviously increased compared with the control group （P〈0.05）. Conclusion NT-proBNP is a reliable diagnostic index of heart failure and closely related to the severity of heart failure. Dynamic observation of NT-proBNP change has important clinical value in evaluating the treatment effect of heart failure and judging the prognosis of heart failure patients.
出处
《现代医药卫生》
2013年第8期1156-1157,共2页
Journal of Modern Medicine & Health
关键词
利钠肽
脑
诊断应用
心力衰竭
诊断
预后
Natriuretic peptide,brain/diagnostic use
Heart failure/diagnosis
Prognosis
