摘要
目的探讨血清铁蛋白(SF)在噬血细胞综合征(HLH)患儿病情监测中的作用。方法回顾性分析2006年5月至2011年5月本院儿科收治的50例初诊HLH住院患儿临床资料,应用放射免疫分析法治疗前、复发时、治疗后检测50例HLH患儿SF水平,HLH患儿全部采用HLH-04治疗方案,比较各组治疗前后SF水平。结果①CR患儿35例中15例复发,复发时SF再次增高,与CR时SF水平比较差异有统计学意义(P<0.01)。②复发时SF水平异常增高,与缓解组相比较差异有统计学意义(P<0.01)。血清铁蛋白水平升高与复发之间相关性分析,r=0.068。结论①血清铁蛋白(SF)水平升高对HLH具有的病情监测价值,血清铁蛋白(SF)水平越高,HLH复发可能性越大;②监测HLH患儿SF水平有助于病情判断,其值变化与病情活动度有关,且对临床疗效有评价作用。
Objective To investigate the role of serum ferritin （SF） on evaluation of monitoring in children with hemophagocytic lymphohistiocytosis（HLH）. Methods Fifty children with HLH from May 2006 to May 2011 were retrospectively analyzed in the Central Hospital of Nanyang City. The levels of SF were detected regularly by radio-immunoassay in 50 children with HLH.All children applied scheme of HLH-04.The levels of SF before and after treatment were compared, and to discuss the clinical value of SF. Results 0）Seven cases with CR recurrenced. The levels of SF increased again when recurrence, which were significantly different with those of CR（P〈0.01）. ~The relation of SF and recurrence is r=0.068.Conclusions O SF is a valuable marker for the evaluation of therapeutic effect of HLH. The SF level washigher, the bigger was reliability for the evaluation of therapeutic effect of HLH. （2）The detecting of SF not only play an importent role in the diagnosis, but also in monitoring recurrence and curative effect assessment of hemopbagocytic lymphohistiocytosis.
出处
《中国医药指南》
2013年第19期55-56,共2页
Guide of China Medicine
关键词
噬血细胞综合征
血清铁蛋白
复发预测
Hemophagocytic lymphohistiocytosis
Serum ferritin
Monitoring recurrence
