摘要
目的探讨肾透明细胞癌中环氧化酶-2（COX-2）、血管内皮细胞生长因子（VEGF）的表达及其相关意义。方法采用免疫组化法检测60例原发性肾透明细胞癌、10例正常肾组织中COX-2和VEGF的表达。结果COX-2在肾透明细胞癌中的阳性表达率（76．7％）高于正常肾组织（20％）（X^2=10．28，P〈0．01）。VEGF在肾透明细胞癌中的阳性表达率（73．3％）高于正常肾组织（20％）（X^2=8．58，P〈0．01）。肾透明细胞癌中COX-2表达与VEGF表达呈正相关（r=0．469，P〈0．01）。结论COX-2、VEGF的表达参与了肾透明细胞癌的发生、发展，COX-2、VEGF的表达可作为肾透明细胞癌发生、发展动态过程中的客观观察指标，二者的协同作用强化了肿瘤的恶性演进。
Objective To study the correlation between vascular endothelial growth factor（VEGF） and cyclooxygenase-2（COX-2） in clear renal cell carcinoma （CRCC）. Methods In 60 cases of CRCC and 10 cases of normal renal tissue, immunohistochemistry was used to examine the expression of COX-2 and VEGF. Results The positive expression rate of COX-2 in CRCC （76. 7% ） was significantly higher than that in normal renal tissue （20%） （ X^2 = 10. 28, P 〈 0. O1 ）. The positive expression rate of VEGF in CRCC（73.3% ） was significantly higher than that in normal renal tissue （20%） （X^2=8.58, P 〈0. 01）. The expressions of COX-2 and VEGF in CRCC were correlated with each other （ r = 0. 469, P 〈 0.01 ）. Conclusions The expressions of COX-2 and VEGF were involved in the pathophysiolical processes of clear renal cell carcinoma. The expression levels of COX-2 and VEGF might be used to evaluate the development of clear renal cell carcinoma.
出处
《中国医师杂志》
CAS
2013年第3期293-295,共3页
Journal of Chinese Physician
基金
辽宁省科技厅科学技术计划项目（2010225032）
关键词
肾肿瘤
病理学
腺癌
透明细胞
病理学
环氧化酶2
代谢
内皮生长因子
代谢
Kidney neoplasms/pathology
Adenocareinoma, clear celL/pathology
Cyclooxygenase 2/metabolism
Endothelial growth factors/metabolism
