摘要
目的:研究维药复方薰衣草糖浆对D-半乳糖(D-gal)致老年痴呆模型小鼠的保护作用。方法:NIH小鼠120只,随机分为六组:正常对照组(NC),模型组(D-gal),维生素E片组,复方薰衣草糖浆低、中、高三个剂量组:分别为4.5ml/kg、9.0ml/kg和18.0ml/kg(分别相当于含生药量0.67g/kg、1.35g/kg和2.70g/kg)。每组小鼠20只。除NC组外,各组小鼠均颈背部iH D-gal50mg/kg。维生素E片组和复方薰衣草糖浆3个剂量组均ig给药,D-gal组和NC组小鼠分别ig等容量生理盐水,每日一次,造模和给药均连续60天。分别以跳台实验、迷宫实验法测定其潜伏期和5min内错误次数,并测定各组小鼠脑组织SOD活性及MDA含量。结果:跳台实验和迷宫实验中,D-gal组潜伏期和5min错误次数均明显高于NC组和各给药组,给药各组均可使潜伏期和5min错误次数明显降低。模型组小鼠脑SOD活性低于、MDA含量则高于NC组,用复方薰衣草糖浆均可使SOD活性明显提高,MDA含量明显降低。结论:复方薰衣草糖浆能显著提高老年痴呆模型小鼠的学习、记忆能力,提高脑组织SOD活性,降低脂质过氧化产物MDA的含量。
Objective：To investigate the protective influence of compound lavender syrups on D-galactose induced senile dementia model mice.Methods：120 NIH mice were randomly divided into six groups（20 per group）：normal control group（NC）,model group（D-gal）,Vitamin E tablets groups,compound lavender syrups groups which were divided into low-,middle-and high-dose：4.5ml/kg、9.0ml/kg and 18.0ml/kg（equivalent to the content of crude drug 0.67g/kg、1.35g/kg and 2.70g/kg respectively）.Except for NC group,other groups were given hypodermic injection of D-gal（50mg/kg）.NC group was given hypodermic injection of NS.Vitamin E tablets group and compound lavender syrups groups were given oral administration.NC group and D-gal group were given oral administration of water.Mice of every group were repeatedly given hypodermic injection and oral administration drugs one time every day.Respectively measured erroneous number in 5 minutes,latent periods,SOD activities,and MDA content after 60 days.Results：Compared with other groups,D-gal group were obviously higher on erroneous in 5minutes which were 11.20±3.10 and 24.19 ±13.01（P0.05 or P0.01）.Compared with other groups,D-gal group were obviously increased latent periods which were 35.61±8.64s and 53.75 ±17.85s（P0.05 or P0.01）.Compared with other groups,D-gal group were obviously decreased SOD activities and increased MDA contents（P0.05 or P0.01）.Conclusion：Our results indicated that compound lavender syrups could improve the function of learning and memory of the senile dementia model mouse,increase SOD activities and decrease MDA of brain.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2013年第1期138-140,共3页
Pharmacology and Clinics of Chinese Materia Medica
