摘要
目的:观察散结消瘿颗粒、海藻玉壶汤加减方(临床用汤剂)对实验性自身免疫性甲状腺炎(EAT)小鼠甲状腺功能及抗体水平的影响。方法:在建立EAT小鼠模型的基础上,设立散结消瘿颗粒(富碘型组和多糖型组)、海藻玉壶汤加减方组(临床用汤剂)、模型组、正常组、对照组,采用化学发光法测定EAT小鼠T3、T4、TGAb、TPOAb。结果:在给予小鼠灌胃54g生药/kg的剂量下,散结消瘿颗粒(富碘型组和多糖型组)对甲状腺激素的调节作用优于临床汤剂海藻玉壶汤组;模型组小鼠血清TGAb水平高于正常组(P<0.01);散结消瘿颗粒组与临床汤剂组相比,TGAb水平呈整体下降趋势,其中富碘型散结消瘿颗粒则优于多糖型散结消瘿颗粒。结论:散结消瘿颗粒(富碘型组及多糖型组)能调节EAT小鼠模型的甲状腺激素及抗体的水平,且具有一定的治疗作用,其效果优于海藻玉壶汤加减方组(临床用汤剂)。
Objective： To observe the effect of Sanjie Xiaoying granule（extract）,Modified Haizao Yuhu Decoction（traditional herbs decoction） on the thyroid function and auto-antibody in experimental autoimmune thyroiditis（EAT） mice.Methods： After mice models of EAT were established,mice models of EAT were divided into Sanjie Xiaoying granule group,Modified Haizao Yuhu Decoction group.And model group,control group and normal group were developed.After treatment T3,T4,TGAb,TPOAb in serum of mice were measured by chemiluminescence immunoassay.Results： Sanjie Xiaoying granule group of thyroid hormone regulation is better than Modified Haizao Yuhu Decoction group.The level of TGAb in the EAT model group was higher than that in the control group（P 0.01）.Conclusion： Sanjie Xiaoying granule can adjust the thyroid hormone and antibody in the EAT rats.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2013年第1期121-124,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
浙江省大学生科技创新活动计划(新苗人才计划)资助项目(2012R410056)
浙江省自然科学基金(Y2110967)
