摘要
目的检测慢性荨麻疹患儿血清IFN-γ、IL-10水平,初步探讨慢性荨麻疹患儿免疫相关发病机制。方法用ELISA法检测78例慢性荨麻疹患儿(观察组)及42例健康儿童(正常对照组)血清中IFN-γ、IL-10水平。结果观察组血清IFN-γ(9.32±2.91,pg/ml)显著低于正常对照组(49.89±9.48,pg/ml);而血清IL-10(7.48±1.81,pg/ml)则明显高于正常对照组(2.96±0.39,pg/ml)。结论慢性荨麻疹儿童存在免疫失衡,表现为免疫抑制状态,使病情反复且迁延不愈。
Objective Detection of serum IFN-γ,IL-10 levels in children with chronic urticaria,to study on immune related mechanism of chronic urticaria in childrenpreliminary.Methods ELISA assay was used to detect IFN-γ,IL-10 level in serum in 78 patients with chronic urticaria patients（observation group） and 42 healthy children（normal control group）.Results In the observation group,the levels of IFN-γ（9.32±2.91,pg/mL） was significantly lower than that of normal control group（49.89±9.48,pg/mL）;and the serum IL-10（7.48± 1.81,pg/ml）was significantly higher than that of normal control group（2.96± 0.39,pg/ml）.Conclusion The presence of immune imbalance in children with chronic urticaria,manifested as immunosuppression.It may cause recurrent and persistent unhealed.
出处
《现代诊断与治疗》
CAS
2013年第6期1201-1202,共2页
Modern Diagnosis and Treatment
基金
惠州市科技计划项目(项目编号:2012Y109)
