摘要
目的运用心肌超声造影技术、应变率显像技术评价急性脑损伤时心肌功能、心肌各节段微循环灌注情况。方法建立18只犬急性颅脑损伤模型,于伤前及伤后6h、1d、3d利用实时心肌声学造影、应变率显像技术检测动物模型左室长轴方向各节段心肌应变率和由心肌再灌注后的时间-密度曲线得出的心肌显像峰值强度、平均斜率及局部心肌血流量等指标。结果 3只犬于伤后6h即出现节段性心肌应变率、心肌显像峰值强度、平均斜率及局部心肌血流量等指标的减低,另有12只犬均在3d内出现相应指标的改变。结论急性脑损伤后,应激状态下中枢性心功能不全易导致心肌损伤继而并发脑心综合症,且多于伤后3d内发病。声学造影技术及应变率显像技术可为临床早期发现心肌损伤及心肌功能异常提供有效指标。
Objective To investigate the application of real-time myocardial contrast echocardiography （RTMCE） on evaluating myocardial function and regional microcirculation in traumatic brain injury （TBI）. Methods In 18 cases canine model of TBI, RTMCE and strain rate imaging were employed to measure the index including strain rate of different myocardial segments, the time-amplitude curves, the mean ascending slope of the curve and local myocardial blood flow with respectively 6 hours, 1 day and 3 day pre and post-TBI. Results Compared with pre-TBI, the segmental myocardial strain rate, the maximal amplitude , the mean ascending slope and myocardial blood flow decreased in 3 cases immediately 6hour after TBI. In 3 days, more significant alteration of previous index was discovered in another 12 cases. Conclusions After acute TBI, myocardial dysfunction in heavy stress responses could result in the cerebral-cardiac syndrome, which develops in 3 days post-TBI. RTMCE and Strain rate imaging clinically provide an earlier way to detect myocardial damage and dysfunction in acute TBI patients.
出处
《临床神经外科杂志》
CAS
2013年第3期164-165,168,共3页
Journal of Clinical Neurosurgery
基金
南京军区医学科研课题基金资助项目(07M002)
关键词
实时心肌声学造影
应变率成像
心肌缺血
脑心综合征
real-time myocardial contrast echocardiography
strain rate imaging
myocardial ischemia
cerebral-cardiac syndrome
