摘要
目的了解艾司西酞普兰联合尼莫地平治疗脑卒中后抑郁的疗效和安全性。方法将88例患者随机分为研究组和对照组,研究组口服艾司西酞普兰(起始剂量10 mg.d-1),同时服用尼莫地平(每次30 mg,3次/天);对照组单一口服艾司西酞普兰,用法、用量同研究组。两组疗程均为6周。抗抑郁效果使用HAMD减分率评定,不良反应使用不良反应量表(TESS)评定,神经功能缺损评定采用CSS评定。结果治疗6周后,研究组抗抑郁总有效率为77.14%,对照组52.78%,两组比较有统计学差异(χ2=4.23,P<0.05),治疗后研究组CSS评分为(12.8±4.2)分,对照组为(14.8±2.1)分,两组评分有统计学差异(t=2.55,P<0.05)。两组不良反应无统计学差异。结论艾司西酞普兰联合尼莫地平治疗脑卒中后抑郁效果优于单用艾司西酞普兰,能明显改善患者的认知和神经功能,且不增加不良反应。
Objective To explore the efficacy and safety of escitalopram combined nimodipine on the treatment of post-stroke depression（PSD）.Methods 88 patients were randomly divided into study group and control group.Study group was given oral escitalopram with an initial dosage of 10 mg·d-1,and nimodipine 30 mg each time,three times a day;and control group was given single escitalopram with the same usage and dosage for 6-week treatment course.Clinical efficacy was evaluated using the reducing score rate of Hamilton Depression Scale（HAMD）,adverse reactions were assessed using treatment emergent symptom scale（TESS）,and the nerve function deficiency was evaluated by CSS.Results After 6 weeks of treatment,the total effective rate was 77.14% and 52.78% in study group and in control group respectively.There was statistical difference between the two groups（χ2=4.23,P0.05）.The scores of CSS in study and control group respetively were（12.8±4.2）and（14.8±2.1）.There was statistical difference between the two groups（t=2.55,P0.05）,but there was no statistical difference in adverse reactions.Conclusions Escitalopram combined nimodipine has higher effect than escitalopram on the treatment of post-stroke depression,and it can obviously improve the cognitive ability and nerves function without any increase in side-effects.
出处
《安徽医药》
CAS
2013年第1期118-119,共2页
Anhui Medical and Pharmaceutical Journal
基金
成都医学院第一附属医院独立资助(No CYFY10DL-007)
