摘要
目的比较辅助生殖技术中促性腺激素释放激素激动剂(GnRH-a)长方案、短方案和促性腺激素释放激素拮抗剂(GnRH-ant)方案对卵巢功能减退患者的促排卵效果及其对临床结局的影响。方法回顾性分析因输卵管因素和/或男方因素在我院生殖中心进行IVF/ICSI助孕且窦卵泡数少于5的患者的临床资料,共169个促排卵周期,比较不同的促排卵方案中患者的一般特点、内分泌激素水平、促性腺激素(Gn)的用药持续时间和药量、获卵数、受精数及临床结局。结果在三组促排卵方案中,患者的一般情况、激素水平、获卵数、受精数之间无统计学差异(P>0.05);短方案和拮抗剂方案组中Gn的用药天数和用药量明显少于长方案组。长方案、短方案及拮抗剂方案的临床妊娠率分别为29.57%、23.45%、33.69%,三组无统计学差异(P>0.05)。结论拮抗剂方案可能是卵巢功能减退患者进行控制性促排卵治疗的一种较好的选择。
Objective： To compare the stimulation effects and the clinical outcomes of GnRH agonist long protocol,GnRH agonist short protocol and GnRH antagonist protocol regimens in decreased ovarian reserve patients in IVF / ICSI cycles.Method： Women for in vitro fertilization（IVF） or intracytoplasmic sperm injection（ICSI）-embryo transfer（ET） therapy due to the tubal and / or male factors were included in this study.169 controlled ovarian stimulation cycles were analyzed.Women general characteristics,basal and hCG day hormones,oocytes retrieved,fertilization,transfer embryos,duration of COS,dosage of ganadotropins and pregnant outcomes were evaluated.Results： There was no significant difference on the general characteristics,hormone levels,retrieved oocytes and fertilization gametes in three protocols（P 0.05）.The usage of gonadotropins and duration of COS in GnRH agonist short protocol and GnRH antagonist protocol groups were significantly less than GnRH agonist long protocol group.The clinical pregnancy rates were 29.57%,23.45%,33.69% respectively in GnRH agonist long,short and antagonist group,there was no significant difference among them（P 0.05）.Conclusion： GnRH antagonist protocol is likely to be an alternative method for COH in decreased ovarian reserve patients.
出处
《中国优生与遗传杂志》
2013年第7期110-112,共3页
Chinese Journal of Birth Health & Heredity
基金
北京市卫生系统高层次人才培养项目(2011-3-071)
国家自然科学基金项目(81170542)
