摘要
目的了解盐酸曲唑酮治疗脑卒中后失眠的疗效和不良反应。方法将84例患者随机分为研究组和对照组,每组各42例,研究组晚饭后服用盐酸曲唑酮50 mg,每天最高剂量不超过100 mg,对照组睡前0.5 h服用阿普唑仑0.8 mg,1周后根据患者反应调整剂量,两组均观察4周。治疗前、治疗每周末采用匹兹堡睡眠质量指数(PSQI)评定睡眠质量,以治疗4周末PSQI减分率评定疗效,采用不良反应量表(TESS)评定药物不良反应。结果治疗4周末,研究组有效率为85.71%(36/42),对照组有效率为92.86%(39/42),两组比较,差异无统计学意义(χ2=0.50,P>0.05)。治疗1周后对照组PSQI低于研究组,差异有统计学意义(t=2.57,P<0.05),治疗2、3、4周时,两组PSQI进一步下降,但组间比较,差异无统计学意义(P>0.05),两组治疗第1周时与治疗前比较,差异均有统计学意义(P<0.01)。研究组TESS评分低于对照组,差异有统计学意义(P<0.05)。结论盐酸曲唑酮治疗脑卒中后失眠疗效与阿普唑仑相似,但不良反应较轻。
Objective To understand the efficacy and adverse reactions of trazodone hydrochloride in the treatment of post-stroke insomnia. Methods 84 cases of post-stroke insomnia were randomly divided into the study group and the control group with 42 cases in each group. The study group was treated with trazodone hydrochloride 50 mg after dinner with the maximum dose not exceeding t00 mg per day ,while the control group was given alprazolam 0.8 mg at 0.5 h before sleep and the dose was adjusted according to the patients＇ reaction after 1 week. The observation period in both groups was 4 weeks. The Pittsburgh Sleep Quality Index （PSQI） was used to evaluate the sleep quality before treatment and at every weekend after treatment, the clinical ef- ficacy was evaluated by the reducing score rate of PSQI after 4-week treatment and the adverse reactions were assessed by the Treatment Emergent Symptom Scale （TESS）. Results After 4-week treatment, the total effective rate was 85.71% in the study group（36/42） and 92.86% in the control group （39/42） ,there was no statistical difference between the two groups （x2=-0.50 ,P〉0.05 ）. PSQI showed that the scores after 1-week treatment in the control group was lower than that in the study group with statistically significant difference （t=2.57, P〈0.05 ）, while PSQI scores after 2,3,4 weeks were declined further without statistical difference between the two groups （P〉0.05）, but the difference of the scores between 1- week treatment and pre-treatment in the two groups had statistical significance （P〈0.01 ）：TESS showed that the scores in the study group was lower than those in the control group with statistically significant difference （P〈0.05）. Conclusion Trazodone hydrochloride has the same effect as alprazolam in the treat- ment of post-stroke insomnia, moreover, the adverse reactions are mild.
出处
《现代医药卫生》
2013年第11期1621-1622,共2页
Journal of Modern Medicine & Health
关键词
卒中
并发症
入睡和睡眠障碍
药物疗法
曲唑酮
治疗应用
治疗结果
Stroke/complications
Sleep initiation and maintenance disorders/drug therapy
Trazodone/therapeutic use
Treatment outcome
