摘要
目的探讨血管紧张素Ⅱ1型受体多态性与冠心病的相关性,提高临床用药效果。方法选择我院于2011年1月至2012年3月心内科住院的患者90例分入冠心病组;选择同期健康体检者(冠心病相关指标检查后均属正常,且无相关病史及家族史)60例分入健康组,采用分组对照的方法比较分析。两组均采用PCR-RFLP技术检测AT1R多态性;通过造影技术检测冠心病组患者的病情严重程度。结果通过AT1R-A1166/C基因观测检测出两种基因:AA型、AC型;AA、AC基因型及等位基因频率(健康组及冠心病组中检测结果没有发现CC型)的检测结果两组比较差异无统计学意义(P>0.05);病变指数及危险统计AC型高于AA型,差异具有统计学意义(P<0.05)。结论血管紧张素Ⅱ1型受体多态性不是冠心病发生的主要原因,但与冠脉病变严重程度有关,该研究结果在临床用药指导中具有重要意义。
Objective To explore the correlation between angiotensin II type 1 receptor gene polymorphism and coronary heart disease, and to improve the effect of clinical medicine. Methods Ninety hospitalized patients in the Department of Cardiology in our hospital from January 2011 to March 2012 were selected as the CHD group, while 60 healthy subjects were enrolled as the control group （coronary heart disease-related indicators are normal, no relevant medical history and family history）. AT1 R polymorphism were detected by PCR-RFLP, the severity of the pa- tient＇s condition was detected by angiography. Results By observing the AT1R-Al166/C, two genes were detected： AA genotype, AC genotyp. The AA, AC genotype and allele frequencies showed no statistically significant difference between the two groups （P〉0.05）. The lesion score and risk statistics for AC genotype were higher than thsoe of AA genotype, and the difference was statistically significnat （P〈0.05）. Conclusion Angiotensin II type 1 receptor gene polymorphism is not the main reason for coronary heart disease, but it is correlated with the severity of coronary artery disease. The results provide great significance in the clinical medication.
出处
《海南医学》
CAS
2013年第14期2040-2042,共3页
Hainan Medical Journal
基金
陕西省科技计划项目(编号2010-D16)
关键词
相关性
多态性
冠心病
Correlation
Polyrnorphism
Coronary heart disease
