摘要
目的 :探讨老年高血压和冠心病患者的胰岛素抵抗及其与血脂的关系。方法 :以胰岛素曲线下面积 /葡萄糖曲线下面积 (I/ G)和胰岛素抵抗指数作为胰岛素抵抗指标 ,与空腹血脂指标进行直线相关分析。结果 :与正常对照组(n=2 0 )比较 ,高血压组 (n=2 5 )与冠心病组 (n=2 0 )的血清甘油三酯 (TG)、低密度脂蛋白 (L DL- C)、空腹胰岛素、空腹胰岛素 /空腹葡萄糖比值、胰岛素曲线下面积、葡萄糖曲线下面积和 I/ G均显著增加 (P<0 .0 5～ 0 .0 0 1) ,而高密度脂蛋白 (HDL- C)、胰岛素抵抗指数 (I I)显著降低 (P<0 .0 5～ 0 .0 0 1) ,冠心病组改变更显著 ;两组的 I/G与 TG、L DL- C呈正相关 (P<0 .0 5～ 0 .0 1) ,与 HDL- C呈负相关 (P<0 .0 1) ,而 与血脂的的关系则与 I/ G相反。正常对照组则上述指标无相关。结论 :老年高血压和冠心病患者存在胰岛素抵抗 。
Objective:To study the insulin resistance(IR) in elderly patients with essential hypertension(EH)and coronary heart disease (CHD).Methods:Linear correlation was analyzed between ratio of area under insulin curve/area under glucose curve(I/G) after oral glucose tolerance test、insulin resistance index(I I) and fasting blood lipids of elderly patients with EH(n=25) and CHD (n=20).Results:Compared normal control group(n=20),serum triglycerides(TG),lower density lipoprotein cholesterol(LDL\|C),fasting insulin,fasting insulin/fasting glucose and I/G were significant increased( P <0 05～0 001);and high density lipoprotein cholesterol(HDL\|C)、I I were significant decreased ( P <0 05～0 001)in EH and CHD group.These alterations are more significant in CHD patients than those in EH.In EH and CHD,the I/G was positively correlated to TG,LDL\|C (p<0 05～0 01),negatively correlated to HDL\|C( P <0 01).The correlation between II and blood lipids was adverse with I/G.However,there was no such correlation between aforesaid indices in the normal control group( P >0 05).Conclusion:There is insulin resistance in elderly patients with EH and CHD,and highly correlated to dyslipidemia. Author′s address Department of Gerontology,the First People's Hospital of Yueyang,Yueyang,414000
出处
《心血管康复医学杂志》
CAS
2000年第4期26-28,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
胰岛素抵抗
高血压
冠状动脉疾病
血脂异常
Insulin resistance
Essential hypertension
Coronary disease
Dyslipidemia
