摘要
脓毒症是一种常见的急性全身性感染,严重脓毒症的病死率极高,且发病率逐年上升.由于脓毒症状态下自由基过量产生,导致微循环血流障碍,进而多脏器功能受损.本文复习了抗坏血酸在脓毒症中的作用,它能通过内皮型一氧化氮合酶依赖的机制迅速扭转脓毒症造成的氧化应激损伤,发挥抗血小板黏附效应,抑制毛细血管栓塞,恢复微循环血流,从而改善患者的生存情况.
Sepsis is a common acute systemic infection,severe sepsis has a high rate of mortality,and its incidence rate is rising year by year.Due to the overproduction of free radicals in sepsis,microcirculation blood is drived disorder,multiple organ function can be impaired.This review describes the role of ascorbic acid in sepsis patients,which can reverse the oxidative stress injury rapidly through an eNOS-dependent mechanism,resisting platelet adhersion,preventing capillary embolism,resevering microcirculation blood flow,so as to improve patients＇ survival.
出处
《国际外科学杂志》
2013年第6期402-404,共3页
International Journal of Surgery
基金
浙江省医药卫生科技计划项目（No.2011KYA074）
浙江省公益技术研究社会发展项目（No.2010C33107）
关键词
脓毒症
抗坏血酸
活性氧
一氧化氮合酶
Sepsis
Ascorbic acid
Reactive oxygen species
Nitric oxide synthase
