摘要
目的研究清胰汤联合肠内营养治疗重症急性胰腺炎的临床疗效。方法151例患者分为观察组(78例)和对照组(73例),均行胃肠减压、补液、抗生素、抑制胰腺分泌等治疗,观察组加用清胰汤鼻饲,肠功能恢复后开始肠内营养。分别观察两组患者腹胀消退时间、禁食时间、胰周感染率,血尿淀粉酶、IL-8、TNF-α、血浆白蛋白、前白蛋白等指标并加以比较。结果观察组清胰腺汤治疗约7～9 d,腹胀消退需5.75±2.15 d,禁食7.02±1.96d;对照组腹胀消退需9.07±3.18 d,禁食14.98±4.18 d。均P<0.01。观察组血尿淀粉酶水平自清胰汤鼻饲后第3天开始显著下降,血清IL-8和TNF-α水平第5天出现显著下降,且第3、5、7天血淀粉酶、血清TNF-α水平较对照组显著降低(P<0.05),第5、7天尿淀粉酶、血清IL-8水平较对照组显著降低(P<0.05)。结论清胰汤能促进肠道功能恢复,减轻全身炎症反应,联合肠内营养可改善患者营养状况。
Objective To study the use on curative effect of Chinese medicine Qing Yi Tang and enteral nutrition in severe acute pancreatitis.Methods 151 cases of severe acute pancreatit were randomly divided into 2 groups,The control group（n=78） and the experimental group（n=73）.Routine treatment were given in both,otherwise,the chinese medicine Qing Yi Tang combined with enteral nutrition were used in the experimental group.Observing and checking two group of the clinical outcomes,the serum IL-8,TNF-α,and the serum albumin,prealbumin.Results The clinical outcomes in experimental groups were significantly better than those of control group,and the levels of IL-8 and TNF-α in serum in experimental groups were significantly lower than those of control group at the same time point（P〈0.05）,which decreased more obviously as the time went on in group at the same time point（P〈0.05）.The patients receiving Qing Yi Tang and enteral nutrition had significantly higher serum albumin and prealbumin level content with shorter hospital stay than those in the control group（P〈0.05）.Conclusion The Chinese medicine Qing Yi Tang can protect gut barrier function by alleviating the damage of intestinal mucosa and microecologic disturbance following acute pancreatitis.Receiving the help of enteral nutrition and Qing Yi Tang,the treatment group get the better treatment effects and clinical outcomes.
出处
《肝胆外科杂志》
2010年第2期109-111,共3页
Journal of Hepatobiliary Surgery
关键词
清胰汤
重症急性胰腺炎
炎症介质
前白蛋白
qing yi tang
severe acute pancreatitis
inflammatory mediators
prealbumin
