摘要
目的观察氢氯噻嗪联合依那普利治疗原发性高血压的疗效及安全性。方法选择原发性高血压患者230例,随机分为两组。对照组予依那普利5～10 mg,每日2次,口服。治疗组在对照组的基础上予氢氯噻嗪12.5～25 mg,每日1次,口服。两组疗程均为3个月。观察其疗效及安全性。结果治疗3个月后,治疗组、对照组降压总有效率分别为100%、62.6%,降压达标率分别为77.3%、47.8%。两组比较差异均有统计学意义(P<0.01)。两组均未见明显不良反应。结论氢氯噻嗪联合依那普利治疗原发性高血压有效、安全、方便、经济。
Objective To observe the clinical effect of hydrochlorothiazide combined with enalapril on patients with essential hypertension and its safety.Methods Two hundred and thirty patients with essential hypertension were randomly divided into two groups： patients in control group（n=115） were treated with enalapril 5-10 mg,twice a day,po;patients in treatment group（n=115） were treated with hydrochlorothiazide（12.5-25 mg,once a day,oral taken） combined with enalapril,three months as a course of treatment.The effects and safety were observed.Results The total effective rate in treatment group was 100%and that in control group was 62.6%.The control rate of the blood pressure in treatment group was 77.3% and that in the control group was 47.8%.There were significant differences between the two groups（P＆lt;0.01）.There were no side effects in the two groups.Conclusion It was effective and safe that hydrochlorothiazide combined with enalapril in treatment of patients with essential hypertension.
出处
《临床医学》
CAS
2013年第6期17-18,共2页
Clinical Medicine
关键词
氢氯噻嗪
依那普利
原发性高血压
Hydrochlorothiazide
Enalapril
Essential hypertension
