摘要
目的观察5%5-氨基酮戊酸光动力疗法治疗中、重度痤疮的临床疗效和安全性。方法将60例中、重度痤疮患者随机分为治疗组和对照组。治疗组根据患者皮损面积配制易透皮吸收的5%5-氨基酮戊酸凝胶外敷于皮损处,避光1h后,戴护目镜,红光照射20min,每周治疗1次,共4次。对照组仅采用红光照射,隔日治疗1次,共14次。每次治疗前进行疗效观察及不良反应记录,两组患者均在治疗4周后,进行疗效判定,随访6个月。结果治疗组5%5-氨基酮戊酸光动力疗法(ALA-PDT)治疗4次后有效率为93.33%,对照组为73.33%,两组差异有统计学意义(P<0.05)。结论 5%5-氨基酮戊酸光动力疗法治疗中重度痤疮安全、有效,疗效优于单用红光。
Objective To evaluate the efficacy and safety of 5-aminolevulinic acid-photodynamic（ALA-PDT） on patients with moderate and severe acne. Methods Sixty patients were randomly divided into treatment group and control group. 5% 5-aminolevulinic acid-mediated photodynamic gel, which was prepared to be easily absorbed according to the extent of skin lesions, was external application to the patients in treatment group. After 1 hour away from light, those patients received a treatment for 20 minutes＇ red laser irradiation wearing goggles once a week, which lasted 4 weeks in all. In control group, only a treatment of red laser irradiation on every other day was applied, which were a total of 14 times treatment. The efficacy was evaluated 4weeks later. All patients were observed and recorded the therapeutic and side effects before every treatment, and were followed up for 6 ： months. Results The total effective rate of two groups was 93.33% and 73.33% respectively after 4-week treatment. There were obvious statistics differences of efficacy between ALA-PDT and red laser only （P 〈 0.05）. Conclusion ALA-PDT which is effective and safe in treatment of moderate and severe ache surpassed the red laser irradiation only.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2013年第7期749-750,共2页
The Chinese Journal of Dermatovenereology
