摘要
消退素是最近发现具有较强抗炎作用的长链多不饱和脂肪酸衍生物家族,可分为E类及阿司匹林触发型等。消退素能在肾组织中天然合成,外源性注射消退素D1可保护缺血再灌注诱发的肾损伤。消退素E1能有效对抗肾脏纤维化,抑制梗阻性肾病中肌成纤维细胞的增生。有研究提示消退素对肾移植排斥反应、内毒素相关肾损伤等具有一定治疗作用。本文就消退素在肾脏疾病领域的研究现状作一综述。
Resolvins are a class of long-chain polyunsaturated fatty acid derivatives newly identified with strong anti-inflammatory biological effects. Resolvins are categorized into D series, E series as well as Aspirin-triggered resolvins. Resolvins can be synthesized naturally in kidney. Exogenous supplementation of Resolvin D1 can protect mice kidneys from ischemia reperfusion injury. By inhibiting proliferation of myofibroblasts, resolvin E1 shows therapeutic effect against renal fibrosis in obstructive nephropathy. Recent studies also reported that resolvins could mitigate lipopolysaccharide-induced kidney injury and allograft rejection in kidney transplant. The present review would summarize researches of resolvins in the field of kidney diseases.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2013年第3期268-271,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
消退素
肾脏病
抗炎
Resolvin Kidney disease Anti-inflammation
