摘要
作者用D-氨基半乳糖造成大鼠急性肝损伤模型.并用肝再生刺激物质(HSS)救治.实验显示治疗组大鼠血浆内氨酸转氨酶(ALT)、内毒素血症(ETM)及肝组织脂质过氧化水平(LPO)与对照组相比,均有不同程度降低,除在中毒后第7日及ALT在中毒后12 h和TTM在72h外.在其它各观察时相相差显著(P<0.05或P<0.01).提示HSS可减轻中毒大鼠TTM.改善肝功能、并有抗氧自由基脂质过氧化作用.这为临床直接应用HSS及胎肝细胞治疗重症肝炎的疗效机理提供了实验依据.
The mechanism of human hepatic stimulative substance (hHSS I for the treatment of experimental acute liver failure was evaluated . The results showed that the plasma levels of alaninc aminotransfcrasc , cndoloxcmia and liver lipid peroxides of chemically poisoned rats were signicanlly reduced by HSS in different extent compared with the saline control group. especially at 24 hours and 48 hours after D - galactosaminc was administrated . hHSS , which can prevent liver deterioration and promote hcpalocylc regeneration , may be a readily available hepatic stimulator factor and can be used clinically .
出处
《第四军医大学学报》
1991年第5期339-341,共3页
Journal of the Fourth Military Medical University
关键词
肝衰竭
肝再生
生长因子
hepatic failure
liver regeneration
growth factor, D - galactosamine
alaninc aminotransferasc
cndotoxcmia
lipid peroxides
